KE, Zhihai

Assistant Professor

Presidential Young Fellow
Education Background

PhD (The Chinese University of Hong Kong)

B.Sc (Sun Yat-sen University)

 

Research Field
Synthetic organic chemistry, organocatalysis, click chemistry, organic framework catalysis
Academic Area
Chemistry, Materials
Email
kezhihai@cuhk.edu.cn
Biography
Ke received his PhD degree from The Chinese University of Hong Kong (CUHK) in 2012. From 2012 to 2015, he did his postdoctoral research in National University of Singapore. He is an Assistant Professor and the director of UG Chemistry Programme at the School of Science and Engineering, The Chinese University of Hong Kong, Shenzhen (CUHKSZ). Before joining CUHKSZ in 2020, he was a research assistant professor in the Department of Chemistry at CUHK. As a PI, he has secured 3 Hong Kong Research Grants Council General Research Funds (GRF). 
 
Ke's research interests include organocatalysis, click chemistry, organic framework catalysis, etc. As the corresponding/first author, he has published more than 30 SCI papers in peer-reviewed international journals such as J. Am. Chem. Soc., Angew. Chem. Int. Ed., ACS Catal., Green Chem., and ChemSusChem. Some of the catalytic methodologies have been highlighted and applied by international colleagues.
Academic Publications

Publications (2018-present):

  1. Applications of Selenonium Cations as Lewis Acids in Organocatalytic Reactions, X. He, X. Wang, Y.-L. Tse, Z. Ke*, Y.-Y. Yeung* Angew. Chem. Int. Ed. 2018, 57, 12869–12873. (Highlighted in Synfact October 2018)
  2. Lewis Base-Promoted Ring-Opening 1,3-Dioxygenation of Unactivated Cyclopropanes using Hypervalent Iodine Reagent, M. H. Gieuw, Z. Ke*, Y.-Y. Yeung* Angew. Chem. Int. Ed. 2018, 57, 3782–3786. (Highlighted in Org. Chem. Highlights, March 18th, 2019)
  3. Desymmetrizing Enantio- and Diastereoselective Selenoetherification through Supramolecular Catalysis, J. Y. See, H. Yang, Y. Zhao, M. W. Wong, Z. Ke*, Y.-Y. Yeung* ACS Catal. 2018, 8, 850–858. (Highlighted in Synfact March 2018)
  4. Environmentally Benign Indole-Catalyzed Position-Selective Halogenation of Thioarenes and Other Aromatics, Y. Shi, Z. Ke*, Y.-Y. Yeung* Green Chem. 2018, 20, 4448–4452.
  5. Electrophilic Bromolactonization of Cyclopropyl Diesters Using Lewis Basic Chalcogenide Catalysts, M. H. Gieuw, V. M. Y. Leung, Z. Ke*, Y.-Y. Yeung* Adv. Synth. Catal. 2018, 360, 4306–4311.
  6. Indole-Catalyzed Bromolactonization: Preparation of Bromolactone in Lipophilic Media, Z. Ke*, T. Chen, Y.-Y. Yeung* Org. Synth. 2018, 95, 256–266.
  7. Lipophilic Indole-Catalyzed Intermolecular Bromoesterification of Olefins in Nonpolar Media, Y. Shi, J. Wong, Z. Ke*, Y.-Y. Yeung* J. Org. Chem. 2019, 84, 4017–4024.
  8. Unearthing the Mechanism of Umpolung Amide Synthesis, Z. Ke, Y.-Y. Yeung* Chem 2019, 5, 1014–1016.
  9. Intermolecular Electrophilic Bromoesterification and Bromoetherification of Unactivated Cyclopropanes,V. M. Y. Leung, M. H. Gieuw, Z. Ke*, Y.-Y. Yeung* Adv. Synth. Catal. 2020, 362, 2039–2044.
  10. Lipophilic indole mediated chemoselective α-monobromination of 1,3-dicarbonyl compounds, J. Wong, Z. Ke*, Y.-Y. Yeung* Tetrahedron. Lett202061, 151772.
  11. Zwitterion-Catalyzed Deacylative Dihalogenation of b-Oxo Amides, Z. Ke*, Y.-P. Lam, K.-S. Chan, Y.-Y. Yeung* Org. Lett. 202022, 7353–7357
  12. Lewis Base Catalyzed Dioxygenation of Olefins with Hypervalent Iodine Reagents, L. Pan, Z. Ke*, Y.-Y. Yeung* Org. Lett. 2021238174–8178. DOI: 10.1021/acs.orglett.1c02872
  13. Bis-selenonium Cations as Bidentate Chalcogen Bond Donors in Catalysis, X. He, X. Wang, Y. -L. Tse*, Z. Ke*, Y. -Y. Yeung* ACS Catal. 2021, 11, 12632-12642.
  14. Autocatalytic aerobic ipso-hydroxylation of arylboronic acid with Hantzsch ester and Hantzsch pyridine, C.-H. Fan, T. Xu, Z. Ke*, Y.-Y. Yeung* Org. Chem. Front.20229, 4091–4096
  15. A Mechanochemical, Catalyst-Free Cascade Synthesis of 1,3-Diols and 1,4-Iodoalcohols Using Styrenes and Hypervalent Iodine Reagents, L. Pan, L. Zheng, Y. Chen, Z. Ke*, Y.-Y. Yeung* Angew. Chem. Int. Ed., 2022, e202207926.
  16. Novel Cu-doped zeolitic imidazolate framework-8 membranes supported on copper foam for highly efficient catalytic wet peroxide oxidation of phenol, Y. Wu, Z. KeMaterials Today Chemistry202224, 100787. 
  17. Amphiphilic indoles as efficient phase-transfer catalysts for bromination in water, Q. Zhang, Y. Xu, X. Liang, Z. KeChemSusChem2022, e202200574.
  18. Hypervalent Chalcogenonium•••π Bonding Catalysis, Q. Zhang, Y.-Y. Chan, M. Zhang, Y.-Y. Yeung, Z. KeAngew. Chem. Int. Ed., 2022, e202208009.
  19. Application of a DIB/BBr3 protocol in metal-free aryl coupling reactions, L. Pan, K.-M. Lee, Z. Ke*, Y.-Y. Yeung* New J. Chem., 2022, 46, 21047–21053.
  20. Applications of the DIB–BBr3 Protocol in Bromination Reactions, L. Pan, K.-M. Lee, Y.-Y. Chan, Z. Ke*, Y.-Y. Yeung* Org. Lett. 2023, 25, 53–57.
  21. Sonodynamic Therapy of NRP2 Monoclonal Antibody-Guided MOFs@COF Targeted Disruption of Mitochondrial and Endoplasmic Reticulum Homeostasis to Induce Autophagy-Dependent Ferroptosis, Z. Zhao, Y. Wu, X. Liang, J. Liu, Y. Luo, Y. Zhang, T. Li, C. Liu, X. Luo, J. Chen, Y. Wang, S. Wang, T. Wu, S. Zhang, D. Yang, W. Li, J. Yan, Z. Ke*, F. Luo* Adv. Sci. 2023, 10, 2303872. 
  22. Metal–Organic Frameworks/Graphdiyne/Copper Foam Composite Membranes for Catalytic Applications, Y. Wu, Y. Yang, Z. Ke* ACS Appl. Mater. Interfaces 2023, 15, 40933–40941.
  23. Visible and Selective Gel Assembly via Covalent Click Chemistry, Y. Zheng, Z. Ke* SmartMat 2023, 4, e1251. doi:10.1002/smm2.1251.

 

Book Chapters:

  1. Furans and Their Benzo Derivatives: Applications, Z. Ke*, Y.-Y. Yeung* Comprehensive Heterocyclic Chemistry IV, Elsevier: Volume 3, 2022, 412–449. DOI: 10.1016/B978-0-12-409547-2.14770-5.
  2. Five-Membered Ring Systems: Furans and Benzofurans, Z. Ke†, G. C. Tsui†, X.-S. Peng†, Y.-Y. Yeung† Progress in Heterocyclic Chemistry, Edited by G. W. Gribble & J. A. Joule; Elsevier: Boston, 2018, 30, 169–195.
  3. Five-Membered Ring Systems: Furans and Benzofurans, Z. Ke†, G. C. Tsui†, X.-S. Peng†, Y.-Y. Yeung† Progress in Heterocyclic Chemistry, Edited by G. W. Gribble & J. A. Joule; Elsevier: Boston, 2017, 29, 239–275.
  4. Five-Membered Ring Systems: Furans and Benzofurans, Z. Ke†, G. C. Tsui†, X.-S. Peng†, Y.-Y. Yeung† Progress in Heterocyclic Chemistry, Edited by G. W. Gribble & J. A. Joule; Elsevier: Boston, 2016, 28, 219–274.
  5. Five-membered ring systems: furans and benzofurans, Z. Ke†, Y.-Y. Yeung†, G. C. Tsui†, X.-S. Peng† Progress in Heterocyclic Chemistry, Edited by G. W. Gribble & J. A. Joule; Elsevier: Boston, 2015, 27, 203–246.