柯志海

助理教授

校长青年学者
教育背景

学士（中山大学）

博士（香港中文大学）

博士后（新加坡国立大学）

研究领域
合成化学；有机催化；点击化学；有机框架催化
学术领域
化学，材料学
港中大（深圳）个人网站
https://myweb.cuhk.edu.cn/kezhihai
电子邮件
kezhihai@cuhk.edu.cn
个人简介

柯志海于2012年在香港中文大学获得博士学位。2012年至2015年在新加坡国立大学化学系从事博士后研究。他是香港中文大学（深圳）本科化学项目负责人，校长青年学者。在2020年加入香港中文大学（深圳）之前，他是香港中文大学化学系的研究助理教授，作为负责人先后主持3项香港研究资助局优配研究基金（GRF）。他获得多项资助（国家自然科学基金、广东省基础与应用基础研究基金、广东省教学创新基金、香港中文大学-香港中文大学（深圳）-广东省联合合作基金、深圳市重点实验室），并荣获亚洲核心项目讲座奖和开放科学杰出作者称号。

柯志海博士的研究兴趣包括有机催化、点击化学、有机框架催化等。他已作为通讯/第一作者在J. Am. Chem. Soc.、Angew. Chem.、ACS Catal.、Adv. Sci.等国际知名学术期刊上发表SCI论文40余篇，部分催化方法学被国际同行点亮并应用。https://myweb.cuhk.edu.cn/kezhihai

学术著作

Publications (2018–present):

  1. Applications of Selenonium Cations as Lewis Acids in Organocatalytic Reactions, X. He, X. Wang, Y.-L. Tse, Z. Ke*, Y.-Y. Yeung*. Angew. Chem. Int. Ed. 2018, 57, 12869–12873. (Highlighted in Synfact, October 2018)
  2. Lewis Base-Promoted Ring-Opening 1,3-Dioxygenation of Unactivated Cyclopropanes using Hypervalent Iodine Reagent, M. H. Gieuw, Z. Ke*, Y.-Y. Yeung*. Angew. Chem. Int. Ed. 2018, 57, 3782–3786. (Highlighted in Org. Chem. Highlights, March 18th, 2019)
  3. Desymmetrizing Enantio- and Diastereoselective Selenoetherification through Supramolecular Catalysis, J. Y. See, H. Yang, Y. Zhao, M. W. Wong, Z. Ke*, Y.-Y. Yeung*. ACS Catal. 2018, 8, 850–858. (Highlighted in Synfact, March 2018)
  4. Environmentally Benign Indole-Catalyzed Position-Selective Halogenation of Thioarenes and Other Aromatics, Y. Shi, Z. Ke*, Y.-Y. Yeung*. Green Chem. 2018, 20, 4448–4452.
  5. Electrophilic Bromolactonization of Cyclopropyl Diesters Using Lewis Basic Chalcogenide Catalysts, M. H. Gieuw, V. M. Y. Leung, Z. Ke*, Y.-Y. Yeung*. Adv. Synth. Catal. 2018, 360, 4306–4311.
  6. Indole-Catalyzed Bromolactonization: Preparation of Bromolactone in Lipophilic Media, Z. Ke*, T. Chen, Y.-Y. Yeung*. Org. Synth. 2018, 95, 256–266.
  7. Lipophilic Indole-Catalyzed Intermolecular Bromoesterification of Olefins in Nonpolar Media, Y. Shi, J. Wong, Z. Ke*, Y.-Y. Yeung*. J. Org. Chem. 2019, 84, 4017–4024.
  8. Unearthing the Mechanism of Umpolung Amide Synthesis, Z. Ke, Y.-Y. Yeung*. Chem 2019, 5, 1014–1016.
  9. Intermolecular Electrophilic Bromoesterification and Bromoetherification of Unactivated Cyclopropanes, V. M. Y. Leung, M. H. Gieuw, Z. Ke*, Y.-Y. Yeung*. Adv. Synth. Catal. 2020, 362, 2039–2044.
  10. Lipophilic indole mediated chemoselective α-monobromination of 1,3-dicarbonyl compounds, J. Wong, Z. Ke*, Y.-Y. Yeung*. Tetrahedron Lett. 2020, 61, 151772.
  11. Zwitterion-Catalyzed Deacylative Dihalogenation of β-Oxo Amides, Z. Ke*, Y.-P. Lam, K.-S. Chan, Y.-Y. Yeung*. Org. Lett. 2020, 22, 7353–7357.
  12. Lewis Base Catalyzed Dioxygenation of Olefins with Hypervalent Iodine Reagents, L. Pan, Z. Ke*, Y.-Y. Yeung*. Org. Lett. 2021, 23, 8174–8178. DOI: 10.1021/acs.orglett.1c02872
  13. Bis-selenonium Cations as Bidentate Chalcogen Bond Donors in Catalysis, X. He, X. Wang, Y.-L. Tse*, Z. Ke*, Y.-Y. Yeung*. ACS Catal. 2021, 11, 12632–12642.
  14. Autocatalytic aerobic ipso-hydroxylation of arylboronic acid with Hantzsch ester and Hantzsch pyridine, C.-H. Fan, T. Xu, Z. Ke*, Y.-Y. Yeung*. Org. Chem. Front. 2022, 9, 4091–4096.
  15. A Mechanochemical, Catalyst-Free Cascade Synthesis of 1,3-Diols and 1,4-Iodoalcohols Using Styrenes and Hypervalent Iodine Reagents, L. Pan, L. Zheng, Y. Chen, Z. Ke*, Y.-Y. Yeung*. Angew. Chem. Int. Ed. 2022, e202207926.
  16. Novel Cu-doped zeolitic imidazolate framework-8 membranes supported on copper foam for highly efficient catalytic wet peroxide oxidation of phenol, Y. Wu, Z. Ke*. Materials Today Chemistry 2022, 24, 100787.
  17. Amphiphilic indoles as efficient phase-transfer catalysts for bromination in water, Q. Zhang, Y. Xu, X. Liang, Z. Ke*. ChemSusChem 2022, e202200574.
  18. Hypervalent Chalcogenonium•••π Bonding Catalysis, Q. Zhang, Y.-Y. Chan, M. Zhang, Y.-Y. Yeung, Z. Ke*. Angew. Chem. Int. Ed. 2022, e202208009.
  19. Application of a DIB/BBr3 protocol in metal-free aryl coupling reactions, L. Pan, K.-M. Lee, Z. Ke*, Y.-Y. Yeung*. New J. Chem. 2022, 46, 21047–21053.
  20. Applications of the DIB–BBr3 Protocol in Bromination Reactions, L. Pan, K.-M. Lee, Y.-Y. Chan, Z. Ke*, Y.-Y. Yeung*. Org. Lett. 2023, 25, 53–57.
  21. Sonodynamic Therapy of NRP2 Monoclonal Antibody-Guided MOFs@COF Targeted Disruption of Mitochondrial and Endoplasmic Reticulum Homeostasis to Induce Autophagy-Dependent Ferroptosis, Z. Zhao, Y. Wu, X. Liang, J. Liu, Y. Luo, Y. Zhang, T. Li, C. Liu, X. Luo, J. Chen, Y. Wang, S. Wang, T. Wu, S. Zhang, D. Yang, W. Li, J. Yan, Z. Ke*, F. Luo*. Adv. Sci. 2023, 10, 2303872. (Top Viewed Article)
  22. Metal–Organic Frameworks/Graphdiyne/Copper Foam Composite Membranes for Catalytic Applications, Y. Wu, Y. Yang, Z. Ke*. ACS Appl. Mater. Interfaces 2023, 15, 40933–40941.
  23. Visible and Selective Gel Assembly via Covalent Click Chemistry, Y. Zheng, Z. Ke*. SmartMat 2024, 5, e1251.
  24. Strategies for the Preparation of Single-Atom Catalysts Using Low-Dimensional Metal–Organic Frameworks. Small 2024, 20, 2403767.
  25. Epitaxial Growth of Unconventional 2H Noble Metals and Crystal Phase-Dependent Selectivity of Pt in Hydrogenation Catalysis. ACS Materials Lett. 2024, 6, 4149–4157.
  26. Computational Modeling and Experimental Approaches for Understanding the Mechanisms of [FeFe]-Hydrogenase. Adv. Sci. 2025, 12, 202408297.
  27. Ultrasound-activated erythrocyte membrane-camouflaged Pt(II) layered double hydroxide enhances PD-1 inhibitor efficacy in triple-negative breast cancer through cGAS-STING pathway-mediated immunogenic cell death. Theranostics 2025, 15(4), 1456–1477.
  28. Phase-Engineered Zirconium MOF-Based Titanium Single-Atom Catalysts: Phase-Dependent Properties and Applications in Biodiesel Synthesis. J. Mater. Chem. A, 2025, 13, 3849-3857.
  29. Undercoordinated two-dimensional Pt nanoring stabilized on a ring-on-sheet nanoheterostructure for highly efficient alkaline hydrogen evolution reaction. Nano Lett. 2025, 8, 3212–3220.
  30. Zwitterionic Dual Halogen Bond-Catalyzed Electrophilic Bromination of Electron-Deficient Arenes under Mild Conditions. ACS Catal. 2025, 15, 4270–4279. (Highlighted in Synfact, April 2025)
  31. Auto-Tandem Chalcogen Bonding Catalysis: Oxaselenolium-Catalyzed Cascade Povarov–Hydrogen-Transfer Reaction. ACS Catal. 2025, 15, doi: 10.1021/acscatal.5c04636.

Book Chapters:

  1. Furans and Their Benzo Derivatives: Applications, Z. Ke*, Y.-Y. Yeung*. Comprehensive Heterocyclic Chemistry IV, Elsevier: Volume 3, 2022, 412–449. DOI: 10.1016/B978-0-12-409547-2.14770-5
  2. Five-Membered Ring Systems: Furans and Benzofurans, Z. Ke†, G. C. Tsui†, X.-S. Peng†, Y.-Y. Yeung†. Progress in Heterocyclic Chemistry, Edited by G. W. Gribble & J. A. Joule; Elsevier: Boston, 2018, 30, 169–195.
  3. Five-Membered Ring Systems: Furans and Benzofurans, Z. Ke†, G. C. Tsui†, X.-S. Peng†, Y.-Y. Yeung†. Progress in Heterocyclic Chemistry, Edited by G. W. Gribble & J. A. Joule; Elsevier: Boston, 2017, 29, 239–275.
  4. Five-Membered Ring Systems: Furans and Benzofurans, Z. Ke†, G. C. Tsui†, X.-S. Peng†, Y.-Y. Yeung†. Progress in Heterocyclic Chemistry, Edited by G. W. Gribble & J. A. Joule; Elsevier: Boston, 2016, 28, 219–274.

  5. Five-membered ring systems: furans and benzofurans, Z. Ke†, Y.-Y. Yeung†, G. C. Tsui†, X.-S. Peng†. Progress in Heterocyclic Chemistry, Edited by G. W. Gribble & J. A. Joule; Elsevier: Boston, 2015, 27, 203–246.