PENG, Xiao-Shui

Associate Professor

Education Background

Ph.D. (The Chinese University of Hong Kong)

M.Phil. (Lanzhou University)

B.Sc. (Lanzhou University)

Research Field
Novel “bio-inspired” strategies and methodologies for the total synthesis of structurally complex and biologically significant natural products; Natural product enabled discovery and application;
Personal Website
Email
xspeng@cuhk.edu.cn
Biography

Xiao-Shui Peng received his BSc and MSc degrees from Lanzhou University in 1999 and 2002, respectively, under the guidance of Professor Xin-Fu Pan. In 2006, he obtained his PhD from The Chinese University of Hong Kong, where he worked on the total synthesis of pallavicinin under the supervision of Henry N. C. Wong. After completing his postdoctoral research fellowship with Professors K. C. Nicolaou and David Y. K. Chen on the cortistatin project at CSL@Biopolis, Singapore, he returned to CUHK as a Research Assistant Professor (2009-2015) and Research Associate Professor (2015-2020). In 2020, he joined School of Science and Engineering as Associate Professor at The Chinese University of Hong Kong (Shenzhen), and is focusing his research themes on the development of eco-friendly synthetic methodologies and novel “bio-inspired” strategies  for the total synthesis of structurally complex and biologically significant natural products, as well as natural product-derived drug discovery.

Academic Publications

[1]. PtCl2‑Catalyzed Cycloisomerization of 1,8-Enynes: Synthesis of Tetrahydropyridine Species. Mirzaei, A.; Peng, X.-S.;* Wong, H. N. C.* Org. Lett. 2019. 21, 3795-3798.

[2]. Stereospecific Iron-Catalyzed Carbon(sp2)–Carbon(sp3) Cross-Coupling with Alkyllithium and Alkenyl Iodides. Lu, X.-L.; Shannon, M.; Peng, X.-S.;* Wong, H. N. C.* Org. Lett. 2019. 21, 2546-2549.

[3]. Ligand-Free Iron-Catalyzed Carbon (sp2)–Carbon (sp2) Oxidative Homo-Coupling of Alkenyllithiums. Zhong, Z.; Wang, Z.-Y.; Ni, S.-F.; Dang, L.;* Lee, H. K.; Peng, X.-S.;* Wong, H. N. C.* Org. Lett. 2019. 21, 700-704.

[4]. Synthetic studies toward lindenane-type dimers via Diels-Alder reaction. Wu, J.-L.; Lu, Y.-S.; Wong, H. N. C.; * Peng, X.-S.* Tetrahedron 2018, 74, 6749-6760.

[5]. Total syntheses of shizukaols A and E. Wu, J.-L.; Lu, Y.-S.; Tang, B.-C.;* Peng, X.-S.* Nat. Commun. 2018, 9, 4040. DOI.10.1038/s41467-018-06245-7.

[6]. Gold(I)-Catalyzed Tandem Cycloisomerization of 1,5-Enyne Ethers by Hydride Transfer. Lu, X.-L.; Lyu, M.-Y.; Peng, X.-S.;* Wong, H. N. C.* Angew. Chem., Int. Ed., 2018, 57, 11365-11368.

[7]. Ligand-Free Iron-Catalyzed Carbon(sp(2))-Carbon(sp(2)) Cross-Coupling of Alkenyllithium with Vinyl Halides. Liu, Q.; Wang, Z.-Y.; Peng, X.-S.;* Wong, H. N. C. * J. Org. Chem. 2018, 83, 6325-6333.

[8]. Asymmetric Total Syntheses of Colchicine, beta-Lumicolchicine, and Allocolchicinoid N-Acetylcolchinol-O-methyl Ether (NCME). Liu, X.; Hu, Y.-J.; Chen, B.; Min, L.; Peng, X.-S.; Zhao, J.; Li, S. P.; Wong, H. N. C.; Li, C. C. Org. Lett. 2017, 19, 4612-4615.

[9]. Total Synthesis of Pallavicinia Diterpenoids: An Overview. Bian, Y.-C.; Peng, X.-S.*; Wong, H. N. C. Tetrahedron Lett. 2016, 72, 5560-5569.

[10]. Iron-catalysed cross-coupling of organolithium compounds with organic halides. Jia, Z.-H.; Liu, Q.; Peng, X.-S.; Wong, H. N. C.* Nat. Commun. 2016, 7:10614 doi: 10.1038/ncomms10614.