菜单总览
— 优秀师资 —

黄宪达

职位:

教授

教育背景:

博士(台湾中央大学信息工程学系)

研究领域
生物信息、基因体学、宏观基因体学、智能生医科技(药物设计、基因检测、精准医疗)、生物数据库设计与开发
个人网站

http://isblab.life.nctu.edu.tw/pi.php?lang=en

Email

huanghsienda@cuhk.edu.cn

个人简介:


黄宪达教授目前担任我校香港中文大学(深圳)理工学院与瓦谢尔计算生物研究院教授。他毕业于台湾中央大学资讯工程学系博士(2003),此前为台湾交通大学生物科技学系讲座教授,曾任职台湾交通大学生物科技学系主任及生物科技学院副院长、台湾生物资讯学会理事长及台湾教育部五年五百亿计划交大生物资讯中心主任。

黄宪达教授的研究主要集中在计算生物、生物信息、基因体学、宏观基因体学、智能生医科技(药物设计、基因检测、精准医疗)、生物数据库设计与开发等领域。过去十年,黄宪达教授共计发表超过130篇论文,其中 SCI Impact Factor 超过10.0 以上者达40篇,其中高声望期刊包含Science, Nucleic Acids Research、Hepatology、PLoS Biology、J. of Clinical Investigation、Circulation、Biomaterial, Oncogene, Nature Immunology与Molecular Cell等。若使用一些客观数据来评量黄教授的研究成果,有十三篇以上的高引用论文(SCI Highly-cited papers)、H-index 为41、总引用次数超过6,000次(Web of Science)与9,800次 (Google Scholar)。

黄宪达教授所开发的 MicroRNA数据库(miRTarBase),目前为国际认可汇集最完整数据之微小RNA生物数据库,已广为全世界科学家所使用,其中主要为来自美国、中国、日本、德国、与英国等,相关论文被引用次数达2000次以上,黄教授的研究在生命科学与生物医药领域有重大影响。

黄宪达教授获得台湾科技部杰出研究奖二次(2010, 2015),吴大猷先生纪念奖-优秀年轻学者(2009)。


学术著作:


1.      miRTarBase update 2018: a resource for experimentally validated microRNA-target interactions. (2018) Nucleic Acids Res., Vol. 46, D1, pp. D296-D302. (SCI, highly-cited paper)

2.      Plants send small RNAs in extracellular vesicles to fungal pathogen to silence virulence genes. (2018) Science, Vol. 360, No. 6393, pp. 1126-1129.

3.      MicroRNA-224 down-regulates Glycine N-methyltransferase gene expression in Hepatocellular Carcinoma. (2018) Scientific Report, Vol.8, No.1, pp.12284.

4.      Large-Scale Functional Analysis of CRP-Mediated Feed-Forward Loops. (2018) Int. J. Mol. Sci., Vol. 19, No.8, pp. E2335.

5.      Ouroboros resembling competitive endogenous loop (ORCEL) in circular RNAs revealed through transcriptome sequencing dataset analysis. (2018) BMC Genomics, Vol.19 (Suppl. 2), pp.171.

6.      MicroRNA-92a Mediates Endothelial Dysfunction in CKD. (2017) J. Am Soc. Nephrology, Vol. 28, No. 11, pp. 3251-3261.

7.      α-ketoglutarate orchestrates macrophage activation through metabolic and epigenetic reprogramming. (2017) Nature Immunology, Vol. 18, No. 9, pp. 985-994.

8.      Bidirectional cross-kingdom RNAi and fungal uptake of external RNAs confer plant protection. (2016) Nature Plants, Vol. 2, pp. 16151. (SCI, highly-cited paper)

9.      Krüppel-Like Factor 4 Regulation of Cholesterol-25-Hydroxylase and Liver X Receptor Mitigates Atherosclerosis Susceptibility. (2017) Circulation, Vol. 136, No. 14, pp. 1315-1330.

10.   dbPTM 2016: 10-year anniversary of a resource for post-translational modification of proteins. (2016) Nucleic Acids Research, Vol. 44, D1, pp. D435-46.

11.   miRTarBase 2016: updates to the experimentally validated miRNA-target interactions database. (2016) Nucleic Acids Research, Vol. 44, D1, pp. D239-47. (SCI, highly-cited paper)

12.   PlantPAN 2.0: an update of plant promoter analysis navigator for reconstructing transcriptional regulatory networks in plants. (2016) Nucleic Acids Research, Vol. 44, D1, pp. D1154-60.

13.   CircNet: a database of circular RNAs derived from transcriptome sequencing data. (2016) Nucleic Acids Research, Vol. 44, D1, pp. D209-15. (SCI, highly-cited paper)

14.   MethHC: a database of DNA methylation and gene expression in human cancer. (2015) Nucleic Acids Research, Vol. 43 (Database issue), pp. D856-61.

15.   Oxidative stress activates endothelial innate immunity via sterol regulatory element binding protein 2 (SREBP2) transactivation of microRNA-92a. (2015) Circulation, Vol. 131, No. 9, pp. 805-14.

16.   The effects of actin cytoskeleton perturbation on keratin intermediate filament formation in mesenchymal stem/stromal cells. (2014) Biomaterials, Vol. 35, No. 13, pp. 3934-44.

17.   miRTarBase update 2014: an information resource for experimentally validated miRNA-target interactions. (2014) Nucleic Acids Research, Vol. 42, pp. D78-85. (SCI, highly-cited paper)

18.   COL11A1 Promotes Tumor Progression, and Predicts Poor Clinical Outcome in Ovarian Cancer. (2013) Oncogene, Vol. 33, No. 26, pp. 3432-40.

19.   Transcribed pseudogene ψPPM1K generates endogenous siRNA to suppress oncogenic cell growth in hepatocellular carcinoma. (2013) Nucleic Acids Research, Vol. 41, No. 6, pp. 3734-47.

20.   Sterol Regulatory Element Binding Protein 2 Activation of NLRP3 Inflammasome in Endothelium Mediates Hemodynamic-Induced Atherosclerosis Susceptibility. (2013) Circulation, Vol. 128, No. 6, pp. 632-42.

21.   Hypoxia-responsive miRNAs target argonaute 1 to promote angiogenesis. (2013) Journal of Clinical Investigation, Vol. 123, No. 3, pp. 1057-67.

22.   Fungal small RNAs as novel effectors to suppress plant immunity by hijacking the host RNAi machinery. Science, Vol. 342, No. 6154, pp. 118-123. (SCI, highly-cited paper)

23.   MicroRNA-122 plays a critical role in liver homeostasis and hepatocarcinogenesis. (2012) Journal of Clinical Investigation, Vol. 122, No. 8, pp. 2884-97. (SCI, highly-cited paper)

24.   Let-7b is a novel regulator of hepatitis C virus replication. (2012) Cellular and Molecular Life Sciences, Vol. 69, No. 15, pp. 2621-33.

25.   Clusters of nucleotide substitutions and insertion/deletion mutations are associated with repeat sequences. (2011) PLoS Biology, Vol. 9, No. 6, e1000622.

26.   RegPhos: a system to explore the protein kinase-substrate phosphorylation network in humans. (2011) Nucleic Acids Research, Vol.39, pp. D777-87.

27.   miRTarBase: a database curates experimentally validated microRNA-target interactions. (2011) Nucleic Acids Research, Vol.39, pp. D163-9. (SCI, highly-cited paper)

28.   miR-103/107 promote metastasis of colorectal cancer by targeting the metastasis suppressors DAPK and KLF4. (2012) Cancer Research, Vol. 72, No. 14, pp. 3631-41. (SCI, highly-cited paper)

29.   Identifying transcriptional start sites of human microRNAs based on high-throughput sequencing data. (2011) Nucleic Acids Research, Vol. 39, No. 21, pp.9345-9356.

30.   Arabidopsis Argonaute 2 Regulates Innate Immunity via miRNA393*-Mediated Silencing of a Golgi-Localized SNARE Gene, MEMB12. (2011) Molecular Cell, Vo. 42, No. 3, pp. 356-366.

31.   Flow-regulation of Krüppel-like Factor 2 Is Mediated by MicroRNA-92a (2011) Circulation, Vol. 124, No. 5, pp. 633-41.

32.   MicroRNA-122, a tumor suppressor microRNA that regulates intrahepatic metastasis of hepatocellular carcinoma. (2009) Hepatology, Vol. 49, No. 5, pp. 1571-82. (SCI, highly-cited paper)