菜单总览
— 优秀师资 —

杜洋

职位:

助理教授

教育背景:

博士 (中国科学技术大学)

学士 (中南大学湘雅医学院)

研究领域
G蛋白偶联受体; 受体生物学;信号转导;结构药理学;基于结构的药物设计
Email

yangdu@cuhk.edu.cn

个人简介:


杜洋,现为美国斯坦福大学研究科学家(Research Scientist),2018年底将入职香港中文大学(深圳)理工学院助理教授、博士生导师。2011年于中国科学技术大学取得博士学位。之后赴斯坦福大学医学院分子与细胞生理学系,师从2012年诺贝尔化学奖得主Brian Kobilka教授从事G蛋白偶联受体(GPCR)相关的博士后研究工作。期间授予美国心脏协会(American Heart Association)全额博士后奖学金和斯坦福心血管研究所资助等,并获得美国密歇根大学安娜堡分校医学院药学系tenure-track助理教授职位(已拒)。主要方向是以β2肾上腺素受体(beta-2 adrenergic receptor)等重要药物靶点的G蛋白偶联受体(GPCR)为对象,研究其与下游信号分子复合物的结构、功能和分子药理特性。GPCR作为人体基因组最大膜蛋白超家族,现今市面约40%药物以其作为药物靶点。迄今已发表28篇高质量SCI论文(9篇第一作者论文),包括在Cell、Nature、JACS、Chem. Sci.等国际顶级期刊等报道的一系列突出的科研成果。同时担任香港中文大学(深圳)科比尔卡创新药物研究院责任研究员,领导研究组继续从事GPCR的研究和新药开发工作。


学术著作:


29 Du Y*, Duc NM*, Hilger D, Kubiak X, Kim HR, Wang L, Bohon J, Kim HR, Wegrecki M, Asuru A, Jeong KM, Lee J, Chance MR, Lodowski DT, Rasmussen SGF, Kobilka BK, Chung KY. Assembly of a GPCR-G protein complex. Under revision

28 Komolov KE*, Du Y* (* co-first author), Duc NM, Betz R, Rodrigues J, Leib RD, Patra D, Skiniotis G, Adams CM, Dror R, Chung KY, Kobilka BK, Benovic JL. Structural and functional analysis of a β2-Adrenergic Receptor Complex with GRK5. Cell (2017) 169: 407-421 –Selected as the Featured Article of the Issue

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27 Das M*, Du Y* (* co-first author), Ribeiro O, Hariharan P, Mortensen JS, Patra D, Skiniotis G, Loland CJ, Guan L, Kobilka BK, Byrne B, Chae, PS. Conformationally preorganized diastereomeric norbornane-based maltosides (NBMs) for membrane protein study: Implications of detergent kink for micellar properties. J. Am. Chem. Soc. (2017) 139: 3072-81

26 Ehsan M*, Du Y* (* co-first author), Scull NJ, Tikhonova E, Tarrasch J, Mortensen JS, Loland CJ, Skiniotis G, Guan L, Byrne B, Kobilka BK, Chae PS. Highly Branched Penta-Saccharide-Bearing Amphiphiles for Membrane Protein Studies. J. Am. Chem. Soc. (2016) 138: 3789-96

25 Sadaf A*, Du Y* (* co-first author), Hariharan P, Mortensen JS, Perez IM, Seven AB, Santillan C, Skiniotis G, Loland CJ, Kobilka BK, Guan L, Byrne B, Chae PS. Dendronic trimaltoside amphiphiles (DTMs) for membrane protein structure study. Chemical Science (2017) 8: 1169-1177

24 Duc NM*, Du Y* (* co-first author), Thorsen TS, Lee SY, Zhang C, Kato H, Kobilka BK, Chung KY. Effective Application of Bicelles for Conformational Analysis of G Protein-Coupled Receptors by Hydrogen/Deuterium Exchange Mass Spectrometry. J. Am. Soc. Mass. Spectrom. (2015) 26: 808-817

23 Das M, Du Y, Mortensen JS, Hariharan P, Lee HS, Byrne B, Loland CJ, Guan L, Kobilka BK, Chae PS. Rationally engineered tandem facial amphiphiles for improved membrane protein stabilization efficacy. ChemBioChem (2018) Accepted

22 Das M, Du Y, Mortensen JS, Bae HE, Byrne B, Loland CJ, Kobilka BK, Chae PS. An engineered lithocholate-based facial amphiphile stabilizes membrane proteins: assessing the impact of detergent modularity on protein stability. Chemistry (2018), accepted

21 Ehsan M, Das M, Stern V, Du Y, Mortensen JS, Hariharan P, Byrne B, Loland CJ, Kobilka BK, Guan L, Chae PS. Steroid-based amphiphiles for membrane protein study: Importance of alkyl spacer for protein stability. ChemBioChem (2018) doi: 10.1002/cbic.201800106

20 Ehsan M, Du Y, Molist I, Seven AB, Hariharan P, Mortensen JS, Ghani L, Loland CJ, Skiniotis G, Guan L, Byrne B, Kobilka BK, Chae PS. Vitamin E-based glycoside amphiphiles for membrane protein structural studies. Organic and Biomolecular Chemistry (2018) DOI: 10.1039/c8ob00270c

19 Ehsan M, Ghani L, Du Y, Mortensen JS, Ribeiro O, Hu H, Skiniotis G, Loland CJ, Kobilka BK, Byrne B, Chae PS. New penta-saccharide-bearing tripod amphiphiles for membrane protein structure studies. Analyst (2017) 142: 3889-3898

18 Hussain H, Du Y, Tikhonova E, Mortensen JS, Ribeiro O, Santillan C, Das M, Loland CJ, Guan L, Kobilka BK, Byrne B, Chae PS. Resorcinarene-based facial glycosides: implication of detergent flexibility on membrane protein stability. Chemistry (2017) doi: 10.1002/chem.201605016

17 Hussain H, Mortensen JS, Du Y, Santillan C, Ribeiro O, Go J, Loland CJ, Guan L, Kobilka BK, Byrne B, Chae PS. Tandem malonate-based glucosides (TMGs) for membrane protein structural study. Scientific Reports (2017) doi: 10.1039/c6cc06147h

16 Woldring DR, Holec PV, Stern LA, Du Y, Hackel, BJ. A gradient of sitewise diversity promotes evolutionary fitness for binder discovery in a three-helix bundle protein scaffold. Biochemistry (2017) 56: 1656-1671

15 Das M, Du Y, Mortensen JS, Ribeiro O, Loland CJ, Kobilka BK, Byrne B, Chae PS. Butane-1,2,3,4-tetraol-based Amphiphilic Stereoisomers for Membrane Protein Study: Importance of Chirality in the Hydrophobic Region. Chemical Science (2017) 8: 1169-1177

14 Cho KH, Scull NJ, Du Y, Hariharan P, Mortensen JS, Loland CJ, Guan L, Kobilka BK, Byrne B, Chae PS. Mesitylene-cored glucoside amphiphiles (MGAs) for membrane protein study: importance of alkyl chain density in detergent efficacy. Chemistry (2016) 10.1002/chem.201603338

13 Bae HE, Mortensen JS, Ribeiro O, Du Y, Ehsan M, Kobilka BK, Loland CJ, Byrne B, Chae PS. Tandem neopentyl glycol maltosides (TNMs) for membrane protein stabilization. Chemical Communications (2016) 52: 12104-12107

12 Cho KH, Hariharan P, Mortensen JS, Du Y, Nielsen AK, Byrne B, Kobilka BK, Loland CJ, Guan L, Chae PS. Isomeric detergent comparison for membrane proteins stability: importance of inter alkyl chain distance and alkyl chain length. ChemBioChem (2016) 17:2334-2339

11 Carr R 3rd, Schilling J, Song J, Carter RL, Du Y, Yoo SM, Cheung JY, Tilley DG, Benovic JL. β-arrestin-biased signaling through the β2-adrenergic receptor promotes cardiomyocyte contraction. Proc. Natl. Acad. Sci. (2016) 113: 4107-16

10 DeVree B, Mahoney J, Velez-Ruiz G, Rasmussen SGF, Kuszak A, Edwald E, Fung JJ, Manglik A, Masureel M, Du Y, Matt R, Pardon E, Steyaert J, Kobilka BK, Sunahara RK. Allosteric coupling from G protein to the agonist binding pocket in GPCRs. Nature. (2016) 535 (7610):182-6

9 Tian X, Irannejad R, Bowman SL, Du Y, Puthenveedu MA, Zastrow M, and Benovic JL. The α-Arrestin ARRDC3 Regulates the Endosomal Residence Time and Intracellular Signaling of the β2-Adrenergic Receptor. J. Biol. Chem. (2016) 291: 14510-25

8 Hussain H, Du Y, Scull NJ, Mortensen JS, Tarrasch J, Loland CJ, Bernadette Byrne B, Kobilka BK, and Chae PS. Accessible mannitol-based amphiphiles (MNAs) for membrane protein solubilisation and stabilization. Chemistry. (2016) 22: 7068-73

7 Cho KH, Du Y, Scull NJ, Hariharan P, Gotfryd K, Loland CJ, Guan L, Byrne B, Kobilka BK, Chae PS. Novel Xylene-Linked Maltoside Amphiphiles (XMAs) for Membrane Protein Stabilisation. Chemistry. (2015) 21: 10008-13

6 Carr R 3rd, Du Y, Quoyer J, Panettieri RA Jr, Janz JM, Bouvier M, Kobilka BK, Benovic JL. Development and characterization of pepducins as Gs-biased allosteric agonists. J. Biol. Chem. (2014) 289: 35668-84.

5 Du Y, Cheng W, Li WF. Expression profiling reveals an unexpected growth-stimulating effect of surplus iron on the yeast Saccharomyces cerevisiae. Mol. and Cells. (2012) 34: 127-132.

4 Du Y*, Shi WW*, He YX, Yang YH, Zhou CZ, Chen Y. Structures of the substrate-binding protein provide insights into the multiple compatible solutes binding specificities of Bacillus subtilis ABC transporter OpuC. Biochemical J. (2011) 436: 283-289.

3 Du Y*, He YX*, Zhang ZY, Yang YH, Shi WW, Frolet C, Di Guilmi AM, Vernet T, Zhou CZ, and Chen Y. Crystal structure of the mucin-binding protein of Spr1345 from Streptococcus pneumoniae. J. of Struct. Biol. 2011, 174: 252-257.

2 Du Y, He YX, Gaowa S, Zhang X, Chen Y, Zhang SC, Zhou CZ. Crystal structures of the apo and GDP-bound forms of a cupin-like protein BbDUF985 from Branchiostoma belcheri tsingtauense. Proteins. 2010, 78(12): 2714-9.

1 He YX, Gui L, Liu YZ, Du Y, Zhou Y, Li P, Zhou CZ. Crystal structure of Saccharomyces cerevisiae glutamine synthetase Gln1 suggests a nanotube-like supramolecular assembly. Proteins. 2009, 76(1): 249-54.