菜单总览
— 优秀师资 —

成贵娟

职位:

助理教授

教育背景:

博士(北京大学)

本科(华中科技大学)

研究领域
计算化学和生物学,酶催化反应的多尺度分子模拟,有机反应机理研究
Email

chengguijuan@cuhk.edu.cn

个人简介:


成贵娟博士2010年6月从华中科技大学化学与化工学院获得学士学位,并于2015年6月于北京大学获得物理化学博士学位,同年9月赴德国马克思-普朗克煤炭研究所(Max-Planck-Institut für Kohlenforschung)从事博士后研究。成博士于2018年7月加入香港中文大学(深圳),任职理工学院以及瓦谢尔计算生物研究院担任助理教授。成博士的研究兴趣包括利用多尺度分子模拟研究酶催化反应机制,结合理论计算和实验(质谱、电化学等)理解化学反应机理等。她在国际主流期刊上已发表17篇论文,其中3篇一作文章单篇引用超过100次,被评为ESI高被引论文。她的博士学位论文被评为北大优秀博士论文并获得施普林格自然出版社颁发的Springer Thesis Prize.


学术著作:


1.       Cheng, G.-J.; Escorcia, A. M.; Rijn, J. F. M..; Thiel, W. MD and QM/MM Studies on CalB-catalyzed Hydrolysis of Propanolol Esters: the Effects of Acyl Moiety. 2018 (in preparation)

2.       Cheng, G.-J.; Drosos, N.; Morandi, B.;Thiel, W. Computational Study of B(C6F5)3-Catalyzed Selective Deoxygenation of 1,2-Diols. ACS Catal. 2018, 8, 1697.

3.       Escorcia, A. M..; Rijn, J. F. M.; Cheng, G.-J.; Thiel, W. Insight into the Promiscuity of Taxadiene Synthase: A Molecular Dynamic Study. J. Comp. Chem. 2018, 39, 1215.

4.       Ma, X.; Mai, S.; Zhou, Y.; Cheng, G.-J.; Song, Q. Dual Role of Ethyl Bromodifluoroacetate in the Formation of Fluorine-containing Heteroaromatic Compounds. Chem. Commun. 2018, 54, 8960.

5.       Drosos, N.; Cheng, G.-J.; Ozkal, E.; Cacherat, B.; Thiel, W.; Morandi, B. Catalytic Reductive Pinacol-Type Rearrangement of Unactivated 1,2-diols through a Concerted, Stereoinvertive Mechanism. Angew. Chem. Int. Ed. 2017, 56, 13377.

6.       Rummelt, S.; Cheng, G.-J.; Gupta, P.; Thiel, W.; Fürstner, A. Hydroxyl-Directed Ruthenium Catalyzed Alkene/Alkyne Coupling: Increased Scope, Stereochemical Implications and Mechanistic Rationale. Angew. Chem. Int. Ed. 2017, 56, 3599.

7.       Jia, J;† Cheng, G.-J.;† Wu, A.; Luan, S. Novel Imprinted Polyethyleneimine Nano-fluorescent Probes with Controllable Selectivity for Recognizing and Adsorbing Metal Ions. RSC Advances 2017, 7, 36048(† equal contribution)

8.       Xie, Y.; Cheng, G.-J.; Lee, S.; Thiel, W.; List, B. Catalytic Asymmetric Vinylogous Prins Cyclization: A Highly Diastereo- and Enantioselective Entry to Tetrahydrofurans. J. Am. Chem. Soc. 2016, 138, 14538.

9.       Zhong, X.-M.;† Cheng, G.-J.;† P.; Chen, P.; Zhang, X.; Yu, Wu, Y.-D. Mechanistic Study on Pd/Mono-N-protected Amino Acid Catalyzed Vinyl–Vinyl Coupling Reactions: Reactivity and E/Z Selectivity. Org. Lett. 2016, 18, 5240. († equal contribution)

10.    Cheng, G.-J.; P.; Chen, P.; Sun, T.-Y.; Zhang, X.; Yu, J.-Q.; Wu, Y.-D. A Combined IM-MS/DFT Study on Pd(MPAA)-Catalyzed Enantioselective C−H Activation: Relay of Chirality through a Rigid Framework. Chem.–Eur. J. 2015, 21, 11180.

11.    Cheng, G.-J.; Zhang, X.; Chung, L. W.; Xu, L.; Wu, Y.-D. Computational Organic Chemistry: Bridging Theory and Experiment by Mechanistic Understanding of Chemical Reactions. J. Am. Chem. Soc. 2015, 137, 1706. (ESI highly cited paper)

12.    Zhou, F.;† Cheng, G.-J.;† Yang, W.;† Long, Y.; Zhang, S.; Wu, Y.-D.; Zhang, X.; Cai, Q. Enantioselective Formation of Cyano-Bearing All-Carbon Quaternary Stereocenters: Desymmetrization by Copper-Catalyzed N-Arylation. Angew. Chem. Int. Ed. 2014, 53, 9555. († equal contribution)

13.    Cheng, G.-J.; Yang, Y.-F.; Liu, P.; Chen, P.; Sun, T.-Y.; Li, G.; Zhang, X.; Houk, K. N.; Yu, J.-Q.; Wu, Y.-D. Role of N-Acyl Amino Acid Ligands in Pd(II)-Catalyzed Remote C–H Activation of Tethered Arenes. J. Am. Chem. Soc. 2014, 136, 894. (ESI highly cited paper)

14.    Yang, Y.-F.;† Cheng, G.-J.;† Liu, P.; Chen, P.; Zhang, X.; Yu, J.-Q.; Wu, Y.-D.; Houk, K. N. Palladium-Catalyzed Meta-Selective C–H Bond Activation with a Nitrile-Containing Template: Computational Study on Mechanism and Origins of Selectivity. J. Am. Chem. Soc. 2014, 136, 344. († equal contribution, ESI highly cited paper)

15.    Cheng, G.-J.; Song, L.-J.; Yang, Y.-F.; Zhang, X.; Wiest, O.; Wu, Y.-D. Computational Studies on the Mechanism of the Copper-Catalyzed sp3-C-H Cross-Dehydrogenative Coupling Reaction. ChemPlusChem 2013, 78, 943 (Frontispiece paper).

16.    Zhu, L.; Zhou, C.; Yang, W.; He, S.; Cheng, G.-J.; Zhang, X.; Lee, C.-S. Formal Syntheses of (±)-Platensimycin and (±)-Platencin via a Dual-Mode Lewis Acid Induced Cascade Cyclization Approach. J. Org. Chem. 2013, 78, 7912.

17.    Zhao, K.; Cheng, G.-J.; Yang, H.; Shang, H.; Zhang, X.; Wu, Y.-D.; Tang, Y. Total Synthesis of Incarvilleatone and Incarviditone: Insight into Their Biosynthetic Pathways and Structure Determination. Org. Lett. 2012, 14, 4878.

18.    Yang, Y.-F.; Cheng, G.-J.; Zhu, J.; Zhang, X.; Inoue, S.; Wu, Y.-D. Silicon-Containing Formal 4pi-Electron Four-Membered Ring Systems: Antiaromatic, Aromatic, or Not? Chem. Eur. J. 2012, 18, 7516.

 

BOOK Cheng, G.-J. “Mechanistic Studies on Transition Metal-Catalyzed C-H Activation Reactions Using Combined Mass Spectrometry and Theoretical Methods” Springer Theses, 2017, ISBN: 978-981-10-4520-2.