菜单总览
— 优秀师资 —

邹滔滔

职位:

助理教授

教育背景:

博士(香港大学)

本科(武汉大学)

研究领域
生物无机化学、化学生物学、药物化学、新药研发
个人网站

https://myweb.cuhk.edu.cn/ttzou/Home/Index

Email

ttzou@cuhk.edu.cn

个人简介:


邹滔滔博士2010年6月毕业于武汉大学化学学院,获得学士学位;2015年2月毕业于香港大学化学系支志明院士课题组,获博士学位;其后三年时间,邹博士分别在英国华威大学化学系Peter J Sadler课题组、香港大学支志明课题组和美国斯科利普斯研究所Schimmel-Yang课题组从事博士后研究工作。2018年3月,邹博士入职香港中文大学(深圳)理工学院助理教授。邹博士的研究兴趣主要集中在化学和生物的交叉领域,尤其是药物化学和化学生物学,包括无机(及部分有机)化合物的体外及体内的抗肿瘤活性、抗癌靶点识别、特定核酸二级结构检测、药物可控释放等。邹博士获得了多个国际和地区奖项,包括SciFinder Future Leaders, Finalist of Reaxys PhD Prize, Springer Theses Prize, Li Ka Shing Prizes, Hong Kong Young Scientist Awards 等。


学术著作:


Representative publications:

1.         Zou, T.;† Lok, C.-N.,† Wan, P.-K., Zhang, Z.-F., Fung, S.-K., Che, C.-M. Anticancer Metal N-Heterocyclic carbene complexes of gold, platinum and palladium, Curr. Opin. Chem. Bio., 2018, 43, 30-36 († equal contribution).

2.         Fung, S. K.;† Zou, T.;† Cao, B.; Lee, P.-Y.; Fung, Y. M. E.; Hu, D.; Lok, C.-N.; Che, C.-M., Cyclometallated Gold(III) Complexes Containing N-Heterocyclic Carbene Ligands Engage Multiple Anti-Cancer Molecular Targets, Angew. Chem. Int. Ed. 2017, 56, 3892-3896. († equal contribution, Very Important Paper).

3.         Fung, S. K.;† Zou, T.;† Cao, B.; Chen, T.; To, W.-P.; Yang, C.; Lok, C.-N.; Che, C.-M., Luminescent platinum(II) complexes with functionalized N-heterocyclic carbene or diphosphine selectively probe mismatched and abasic DNA, Nat. Commun. 2016, 7, 10655. († equal contribution).

4.         Zou, T.;† Zhang, J.-J.;† Cao, B.; Tong, K.-C.; Lok, C.-N.; Che, C.-M. Deubiquitinases as Anticancer Targets of Gold Complexes, Isr. J. Chem. 2016, 2016, 56, 825-833.

5.         Zou, T., Anti-Cancer N-Heterocyclic Carbene Complexes of Gold(III), Gold(I) and Platinum(II): Thiol "Switch-on" Fluorescent Probes, Thioredoxin Reductase Inhibitors and Endoplasmic Reticulum Targeting Agents; Springer Theses, Springer, 2016.

6.         Zou, T.; Lum, C. T.; Lok, C.-N.; Zhang, J.-J.; Che, C.-M., Chemical biology of anticancer gold(III) and gold(I) complexes. Chem. Soc. Rev. 2015, 44, 8786-8801 (Outside Front Cover).

7.         Tsai, J. L.-L.;† Zou, T.;† Liu, J.; Chen, T.; Chan, A. O.-Y.; Yang, C.; Lok, C.-N.; Che, C.-M., Luminescent platinum(ii) complexes with self-assembly and anti-cancer properties: hydrogel, pH dependent emission color and sustained-release properties under physiological conditions. Chem. Sci. 2015, 6, 3823-3830 († equal contribution).

8.         Zou, T., Sadler, P. J. Speciation of precious metal anti-cancer complexes by NMR spectroscopy. Drug Discov. Today Technol. 2015, 16, 7-15.

9.         Zou, T., Hung, F.-F., Yang, C., Che, C.-M. Strongly Phosphorescent Transition-Metal Complexes with N-Heterocyclic Carbene Ligands as Cellular Probes. In: Luminescent and Photoactive Transition Metal Complexes as Biomolecular Probes and Cellular Reagents Vol. 165 (Ed.: Lo, K. K.-W.). Springer Berlin Heidelberg, 2015, pp. 181-203.

10.     Zou, T.; Lum, C. T.; Lok, C.-N.; To, W.-P.; Low, K.-H.; Che, C.-M., A Binuclear Gold(I) Complex with Mixed Bridging Diphosphine and Bis(N-Heterocyclic Carbene) Ligands Shows Favorable Thiol Reactivity and Inhibits Tumor Growth and Angiogenesis In Vivo. Angew. Chem. Int. Ed. 2014, 53, 5810-5814.

11.     Zou, T.;† Liu, J.;† Lum, C. T.; Ma, C.; Chan, R. C.-T.; Lok, C.-N.; Kwok, W.-M.; Che, C.-M., Luminescent Cyclometalated Platinum(II) Complex Forms Emissive Intercalating Adducts with Double Stranded DNA and RNA: Differential Emissions and Anticancer Activities. Angew. Chem. Int. Ed. 2014, 53, 10119-10123 († equal contribution).

12.     Lok, C.-N.;† Zou, T.;† Zhang, J.-J.; Lin, I. W.-S.; Che, C.-M., Controlled-Release Systems for Metal-Based Nanomedicine: Encapsulated/Self-Assembled Nanoparticles of Anticancer Gold(III)/Platinum(II) Complexes and Antimicrobial Silver Nanoparticles. Adv. Mater. 2014, 26, 5550-5557 († equal contribution).

13.     Zou, T.; Lum, C. T.; Chui, S. S.-Y.; Che, C.-M., Gold(III) Complexes Containing N-Heterocyclic Carbene Ligands: Thiol “Switch-on” Fluorescent Probes and Anti-Cancer Agents. Angew. Chem. Int. Ed. 2013, 52, 2930-2933 (Very Important Paper).

14.     Zou, T.; Lok, C.-N.; Fung, Y. M. E.; Che, C.-M., Luminescent organoplatinum(ii) complexes containing bis(N-heterocyclic carbene) ligands selectively target the endoplasmic reticulum and induce potent photo-toxicity. Chem. Commun. 2013, 49, 5423-5425.