菜单总览
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KOBILKA, Brian

职位:

荣誉教授、2012诺贝尔化学奖获得者、美国国家科学院院士

教育背景:

医学博士(耶鲁大学)

理学学士(美国明尼苏达大学)

研究领域
表征G蛋白偶联受体活化的结构和机制
个人网站

http://kobilkalab.stanford.edu/

Email

kobilka@stanford.edu

个人简介:


    布莱恩·科比尔卡,美国斯坦福大学医学院分子和细胞生理学教授和博士。他也是ConfometRx,一家专注于G-蛋白偶联受体的生物技术公司的共同创办人。在2011年他成为美国国家科学院院士。2012年因在G蛋白偶联受体方面的成就获得诺贝尔化学奖。


学术著作:


部分学术著作

1. Sounier, R. Mas, C, Steyaert, J., Laeremans, T. Manglik, A., Huang, W., Kobilka, B.K., Demene, H., Granier, S. Propagation of conformational changes during μ-opioid receptor activation. Nature August 2015.

2. Huang, W., Manglik, A., Venkatakrishnan, A.J., Laeremans, T., Feinberg, E.N., Sanborn, A.L., Kato, H.E., Livingston, K.E., Thorsen, T.S., Kling, R.C., Granier, S., Gmeiner, P., Husbands, S.M., Tryanor, J.R., Weis, W.I., Steyaert, J., Dror, R.O., Kobilika, B.K. Structural Insights into μ-opioid receptor activation. Nature August 2015.

3. Dror, R. O., Mildorf, T. J., Hilger, D., Manglik, A., Borhani, D. W., Arlow, D. H., Philippsen, A., Villanueva, N., Yang, Z., Lerch, M. T., Hubbell, W. L., Kobilka, B. K., Sunahara R. K., and Shaw, D. E.  Structural basis for nucleotide exchange in heterotrimeric G proteins. Science 348(6241), 1361-1365 (2015).

4. Manglik, A., Kim, T. H., Masureel, M., Altenbach, C., Yang, Z., Hilger, D., Lerch, M. T., Kobilka, T. S.,Thian, F. S., Hubbell, W. L., Prosser, R. S., and Kobilka, B. K. Structural insights into the dynamic process of β2-adrenergic receptor signaling. Cell 161(5), 1101-1111 (2015).

5. Alsteens, D., M. Pfreundschuh, C. Zhang, P. M. Spoerri, S. R. Coughlin, B. K. Kobilka and D. J. Muller. Imaging G protein-coupled receptors while quantifying their ligand-binding free-energy landscape. Nat Methods July (2015).

6. Thorsen, T. S., Matt, R., Weis, W. I. and Kobilka, B. K. Modified T4 Lysozyme Fusion Proteins Facilitate G Protein-Coupled Receptor Crystallogenesis. Structure 22, 1657-1664 (2014).

7. Shukla, A.K., Westfield, G.H., Xiao, K., Reis, R.I., Huang, L.-Y., Tripathi-Shukla, P., Qian, J., Li, S., Blanc, A., Oleskie, A.N., Dosey, A.M., Su, M., Liang, C.-R., Gu, L.-L., Shan, J.-M., Chen, X., Hanna, R., Choi, M., Yao, X.J., Klink, B.U., Kahsai, A.W., Sidhu, S.S., Koide, S., Penczek, P.A., Kossiakoff, A.A., Woods Jr, V.L., Kobilka, B.K., Skiniotis, G. and Lefkowitz, R.J. Visualization of arrestin recruitment by a G-protein-coupled receptor. Nature 512, 218-22 (2014).

8. Staus, D. P., Wingler, L. M., Strachan, R. T., Rasmussen, S. G., Pardon, E., Ahn, S., Steyaert, J., Kobilka, B. K.  and Lefkowitz, R. J. Regulation of beta2-adrenergic receptor function by conformationally selective single-domain intrabodies. Mol Pharmacol 85(3), 472-481 (2014).

9. Kruse, A.C., Ring, A.M., Manglik, A., Hu, J., Hu, K., Eitel, K., Hübner, K., Pardon, E., Valant, C., Sexton, P.M., Christopoulos, A., Felder, C.C., Gmeiner, P., Steyaert, J., Weis, W.I., Garcia, K.C., Wess, J., Kobilka, B.K. Activation and allosteric modulation of a muscarinic acetylcholine receptor. Nature 504, 101-6 (2013).

10. Ring, A.M., Manglik, A., Kruse, A.C., Enos, M.D., Weis, W.I., Garcia, K.C., Kobilka, B.K. Adrenaline-activated structure of the beta 2-adrenoceptor stabilized by an engineered nanobody. Nature 502, 575-579 (2013).

11. Shukla, A. K., Manglik, A., Kruse, A.C., Xiao, Reis, K. R. I., Tseng, W. C., Staus, D. P., Hilger, D., Uysal, S., Huang, L. Y., Paduch, M., Tripathi-Shukla, P., Koide, A., Koide, S., Weis, W. I., Kossiakoff, A. A., Kobilka, B. K.  and Lefkowitz, R. J. Structure of active beta-arrestin-1 bound to a G-protein-coupled receptor phosphopeptide. Nature 497, 137-141 (2013).

12. Nygaard, R., Zou, Y., Dror, R. O., Mildorf, T. J., Arlow, D. H., Manglik, A., Pan, A. C., Liu, C. W., Fung, J. J., Bokoch, M. P., Thian, F. S., Kobilka, T. S., Shaw, D. E., Mueller, L., Prosser, R. S. & Kobilka, B. K. The Dynamic Process of beta(2)-Adrenergic Receptor Activation. Cell 152, 532-542 (2013).

13. Zhang, C., Srinivasan, Y., Arlow, D. H., Fung, J. J., Palmer, D., Zheng, Y., Green, H. F., Pandey, A., Dror, R. O., Shaw, D. E., Weis, W. I., Coughlin, S. R. & Kobilka, B. K.High-resolution crystal structure of human protease-activated receptor 1. Nature 492, 387-392 (2012).

14. Zou, Y., Weis, W. I. & Kobilka, B. K. N-terminal T4 lysozyme fusion facilitates crystallization of a G protein coupled receptor. PLoS One 7, e46039 (2012).

15. Chung, K.Y., Kim, T.H., Manglik, A., Alvares, R., Kobilka, B.K., and Prosser, R.S. The role of detergents on conformational exchange of a G protein-coupled receptor. J Biol Chem 287, 36305-36311 (2012).