菜单总览
— 优秀师资 —

朱宝亭

职位:

教授、副院长

教育背景:

博士(美国德州大学)

硕士、学士(复旦大学上海医学院医学系)

研究领域
分子药理学和药物作用的机理;预防和治疗癌症的药物;退化性疾病(如阿尔茨海默氏病,帕金森氏病);分子化学机理;记忆和认知的分子机理
个人网站

https://sites.google.com/site/cuhkssezhulab/home

Email

btzhu@cuhk.edu.cn

个人简介:


    朱宝亭于1980-1988年就读复旦大学上海医学院,获医学学士学位和药理学硕士学位。1992年获美国德州大学药理学博士。1994-1998年,在世界著名癌症药理学家、美国国家科学院院士A. H. Conney教授指导下工作,先为博士后研究员,后为助理研究教授。1998年受聘美国南卡罗来纳大学任助理教授。在以后的六年时间里,被多次破格晋升,为药理学终身副教授(2002年),药理学终身教授(2004年),和药理学冠名杰出教授(2005)。一年后,又被任命为南卡罗来纳州药学院系主任。2007年应邀加盟堪萨斯大学医学院任肿瘤研究终身冠名杰出教授, 同时任药理学终身教授及堪萨斯大学癌症中心肿瘤生物学研究组领军人。朱宝亭是一位优秀的细胞和分子药理学专家,2012年入选中组部千人计划(创新人才),现任香港中文大学(深圳)理工学院讲座教授、科研副院长。

    朱宝亭的研究领域涵盖基础分子药理学、肿瘤药理学、及疾病分子机理学。主要研究重点是关于甾体激素及食源性化合物在癌症预防和治疗中的作用以及它们在细胞和分子水平上的作用机理。已在国际上以第一或通讯作者发表了近130余篇高质量科学论文,包括New Engl J Med、PNAS、Cancer Res、J Biol Chem、Biochemistry、Biochem J、Endocrinology、BBA-Mol Cell Res、JPET、Mol Pharmacol、Br J Pharmacol 等国际知名杂志。朱宝亭的研究工作已在国际上受到了广泛的认可和关注。所发表的文章,常被杂志选作封面并加注特别报道, 并为多种国际核心杂志撰写特邀综述及述评。论文已被引用约7000次(Google Scholar)。

    多年来朱宝亭实验室受到美国国立卫生研究院(作为四个NIH RO1大型科研基金资助项目的首席研究员,P.I.)、美国癌症协会、其他科研协会机构、及所在的大学在科研经费上的资助。另外,他也常被应邀在多种学术场合讲学和作学术报告,并获得学术方面的多种荣誉和佳奖。还应邀任 Cancer Res、Endocrinology、JPET、PNAS等三十余种国际专业杂志审稿者或编委,并任美国国立卫生研究所 (NIH)、美国国立自然科学基金(NSF) 、瑞士国家科学基金会、香港研究资助局等科研基金的评审委员。


学术著作:


1. Wang P, Mills LH, Song JH, Yu J and Zhu BT* [2017] Lack of cell proliferative and tumorigenic effects of 4-hydroxyestradiol in the anterior pituitary of rats: Role of ultra-rapid O-methylation catalyzed by pituitary membrane-bound catechol-O-methyltransferase. Chemical Research in Toxicology 2017 (in press)

2.  Wang P and Zhu BT* [2017] Unique effect of 4-hydroxyestradiol and its methylation metabolites on lipid and cholesterol profiles in ovariectomized female rats. European Journal of Pharmacology 800: 107-117. [PMID: 28219710]

3. Okada K, Fukui M and Zhu BT* [2016] Protein disulfide isomerase mediates glutathione depletion-induced cytotoxicity. Biochemical and Biophysical Research Communications 477: 495-502. [PMID: 27317486] 

4. Wang P, Dang L and Zhu BT* [2016] Use of computational modeling approaches in studying the binding interactions of compounds with human estrogen receptors. Steroids 105: 26–41. [PMID: 26639429]

5. Ding J and Zhu BT* [2016] Unique dose-dependent effects of human pregnancy hormone estriol on the ratio of blood IgM to IgG in female mice. Molecular Medicine Reports 13: 447-452. [PMID: 26531070]

6. Yamabe N, Kang KS, Lee W, Kim SN and Zhu BT* [2015] Estriol blunts postprandial blood glucose rise in male rats through regulating intestinal glucose transporters. American Journal of Physiology — Endocrinology and Metabolism 308: E370-E379. [PMID: 25516546]  

7. Fukui M, Yamabe N, Choi HJ, Polireddy K, Chen Q and Zhu BT* [2015] Mechanism of Ascorbate-Induced Cell Death in Human Pancreatic Cancer Cells: Role of Bcl-2, Beclin 1 and Autophagy. Planta Medica 81: 838-846. [PMID: 26132849] 

8. Tang Y, Chen R, Huang Y, Li G, Huang Y, Chen J, Duan L, Zhu BT, Thrasher JB, Zhang X and Li B [2014] Natural compound alternol induces oxidative stress-dependent apoptotic cell death preferentially in prostate cancer cells. Molecular Cancer Therapeutics 13: 1526-1536. [PMID: 24688053] 

9. Choi HJ and Zhu BT* [2014] Role of cyclin B1/Cdc2 in mediating Bcl-XL phosphorylation and apoptotic cell death following nocodazole-induced mitotic arrest. Molecular Carcinogenesis 53: 125-137. [PMID: 22949227] 

10. Zhang EY and Zhu BT* [2014] Estriol strongly inhibits DNCB-induced contact dermatitis: Role of antigen-specific antibodies in pathogenesis. Endocrine Connections 3: 161-172. [PMID: 25150251] 

11. Wang P, McInnes C and Zhu BT* [2013] Structural characterization of the binding interactions of various endogenous estrogen metabolites with human estrogen receptor α and β subtypes: A molecular modeling study. PLoS ONE 8(9): e74615. [PMID: 24098659] 

12. Wang P and Zhu BT* [2013] Usefulness of the molecular modeling approach in characterizing the ligand-binding sites of proteins: Experience with studying human PDI, PDIp and COX. Current Medicinal Chemistry 20: 3840-3854. [PMID: 23931275] 

13. Jiang XR, Wang P, Smith CL and Zhu BT* [2013] Synthesis of novel estrogen receptor antagonists using metal-catalyzed coupling reactions and characterization of their biological activity. Journal of Medicinal Chemistry 56: 2779-2790. [PMID: 23448346] 

14. Kang KS, Yamabe N, Wen Y, Fukui M and Zhu BT* [2013] Beneficial effects of natural phenolics on levodopa methylation and oxidative neurodegeneration. Brain Research 1497: 1-14. [PMID: 23206800] (Figure 7 of this paper was featured on the journal cover for that issue.) 

15. Fukui M, Kang KS, Okada K and Zhu BT* [2013] EPA, an omega-3 fatty acid, induces apoptosis in human pancreatic cancer cells in vitro and in vivo: Role of ROS accumulation, caspase 8 activation, and autophagy induction. Journal of Cellular Biochemistry 114: 192-203. [PMID: 22903547]

16. Zhu BT* [2012] Natural compounds as cancer chemopreventive and chemotherapeutic agents: Insights gained from mechanistic and pharmacologic studies. Anticancer Agents in Medicinal Chemistry 12: 1-2. [PMID: 22583401] (Invited Editorial)

17. Fu X, Wang P, Fukui M, Long C, Yin L, Choi HJ and Zhu BT* [2012] PDIp is a major intracellular oestrogen-storage protein that modulates tissue levels of estrogen in the pancreas. Biochemical Journal 447: 115-123. [PMID: 22747530] 

18. Choi HJ and Zhu BT* [2012] Critical role of cyclin B1/Cdc2 up-regulation in the induction of mitotic prometaphase arrest in human breast cancer cells treated with 2-methoxyestradiol. Biochimica et Biophysica Acta 1823: 1306-1315. [PMID: 22580043] 

19. Fukui M, Choi HJ and Zhu BT* [2012] Rapid generation of mitochondrial superoxide induces mitochondron-dependent but caspase-independent cell death in hippocampal neuronal cells that morphologically resembles necroptosis. Toxicology and Applied Pharmacology 262: 156-166. [PMID: 22575170] 

20. Choi HJ, Fukui M and Zhu BT* [2011] Role of cyclin B1/Cdc2 up-regulation in the development of mitotic prometaphase arrest in human breast cancer cells treated with nocodazole. PLoS ONE 6: e24312. [PMID: 21918689] 

21. Zhou R, Lai Y, Yamabe N, Fukui M and Zhu BT* [2011] Estriol has different effects from 17β-estradiol in modulating mouse splenocyte function under inflammatory conditions. Journal of Immunotoxicology 8: 346-358. [PMID: 22017689]

22. Fu XM, Wang P and Zhu BT* [2011] Characterization of the estradiol-binding site structure of human protein disulfide isomerase (PDI). PLoS ONE 6(11): e27185. [PMID: 22073283] 

23. Tan X, Poulose EM, Raveendran VV, Zhu BT, Stechschulte DJ and Dileepan KN* [2011] Regulation of the expression of cyclooxygenases and production of prostaglandin I2 and E2 in human coronary artery endothelial cells by curcumin. Journal of Physiology and Pharmacology 62: 21-28. [PMID: 21451206]

24. Fu XM and Zhu BT* [2011] Both PDI and PDIp can form stable disulfide-linked complexes with thermally-unfolded RNase containing native disulfide bonds: Insights into the disulfide recognition. Biochimica et Biophysica Acta 1814: 487-495 [PMID: 21238616] 

25. Fu XM, Wang P and Zhu BT* [2011] Characterization of the estradiol-binding site structure of human pancreas-specific protein disulfide isomerase: Indispensable role of the hydrogen bond between PDIp-His278 and the estradiol 3-hydroxyl group. Biochemistry 50: 106-115 [PMID: 21080683]

26. Choi HJ, Kang KS, Fukui M and Zhu BT* [2011] Role of JNK‒p53‒GADD45α apoptotic cascade in oxidative stress-induced neuronal death. British Journal of Pharmacology 162: 175-192. [PMID: 20955365] 

27. Wang Y, Denisova JV, Kang KS, Fontes JD, Zhu BT and Belousov AB* [2010] Neuronal gap junctions are required for NMDA receptor-mediated excitotoxicity: Implications in ischemic stroke. Journal of Neurophysiology 104: 3551-3556 [PMID: 20943940]

28. Zhu BT*, Wu KY, Wang P, Cai MX and Conney AH [2010] O-Methylation of catechol estrogens by human placental catechol-O-methyltransferase: Inter-individual differences in sensitivity to heat inactivation and to inhibition by dietary polyphenols. Drug Metabolism and Disposition 38: 1892-1899. [PMID: 20606002] 

29. Wang P, Bai HW and Zhu BT* [2010] Structural basis for certain naturally occurring bioflavonoids to function as reducing co-substrates of cyclooxygenase I and II. PLoS ONE 5(8): e12316. [PMID: 20808785] 

30. Kang KS, Wen Y, Yamabe N, Fukui M, Bishop SC and Zhu BT* [2010] Dual beneficial effect of (-)-epigallocatechin gallate on levodopa methylation and neurodegeneration: in vitro and in vivo studies. PLoS ONE 5(8): e11951. [PMID: 20700524] 

31. Fu XM and Zhu BT* [2010] Human pancreas-specific protein disulfide isomerase (PDIp) can function as a chaperone independently of its enzymatic activity by forming stable complexes with denatured substrate proteins. Biochemical Journal 429: 157-169. [PMID: 20423326] 

32. Kang KS, Wang P, Yamabe N, Fukui M, Jay T and Zhu BT* [2010] Docosahexaenoic acid induces apoptosis in MCF-7 cells in vitro and in vivo via reactive oxygen species formation and caspase 8 activation. PLoS ONE 5(4): e10296. [PMID: 20421971] 

33. Yamabe N, Kang KS and Zhu BT* [2010] Beneficial effect of 17β-estradiol on hyperglycemia and islet β-cell functions in a streptozotocin-induced diabetic rat model. Toxicology and Applied Pharmacology 249: 76-85 [PMID: 20801139]

34. Fukui M, Choi HJ and Zhu BT* [2010] Mechanism for the protective effect of resveratrol against glutamate-induced neuronal death in HT22 cells. Free Radical Biology and Medicine 49: 800-813 [PMID: 20542495] 

35. Fukui M, Yamabe N, Kang KS and Zhu BT* [2010] Growth-stimulatory effect of resveratrol in human cancer cells. Molecular Carcinogenesis 49: 750-759 [PMID: 20572158] 

36. Zhu BT* [2010] Development of selective immune tolerance towards the allogeneic fetus during pregnancy: Role of tryptophan catabolites. International Journal of Molecular Medicine 25: 831-835. [PMID: 20428785] 

37. Fukui M, Yamabe N and Zhu BT* [2010] Resveratrol attenuates the anticancer efficacy of paclitaxel in human breast cancer cells in vitro and in vivo. European Journal of Cancer 46: 1882-1891. [PMID: 20223651] 

38. Fukui M and Zhu BT* [2010] Mitochondrial superoxide dismutase SOD2, but not cytosolic SOD1, plays a critical role in protection against glutamate-induced oxidative stress and cell death in HT22 neuronal cells. Free Radical Biology and Medicine 48: 821-830. [PMID: 20060889]

39. Zhu BT* [2010] On the general mechanism of selective induction of cytochrome P450 enzymes by chemicals: Some theoretical considerations. Expert Opinions on Drug Metabolism and Toxicology 6: 483-494. [PMID: 20113197]

40. Bai HW and Zhu BT* [2010] Myricetin and quercetin are naturally occurring co-substrates of cyclooxygenases in vivo. Prostaglandins, Leukotrienes and Essential Fatty Acids 82: 45-50. [PMID: 19897347] 

41. Dai X and Zhu BT* [2010] Indoleamine 2,3-dioxygenase tissue distribution and cellular localization in mice: Implications for its biological functions. Journal of Histochemistry and Cytochemistry 58: 12-28. [PMID: 19741271]

42. Fu XM, Dai X, Ding J and Zhu BT* [2009] Tissue distribution and cellular localization of protein disulfide isomerase homolog A2 (PDIA2) in various mouse tissues and human pancreas: Implications for functions. Journal of Molecular Histology 40: 189-199. [PMID: 19821078] 

43. Zhang EY, Chen AY and Zhu BT* [2009] Mechanism of dinitrochlorobenzene-induced dermatitis in mice: Role of specific antibodies in pathogenesis. PLoS ONE 4(11): e7703. [PMID: 19890385] 

44. Fukui M, Song JH, Choi JY, Choi HJ and Zhu BT* [2009] Mechanism of glutamate-induced neurotoxicity in culture HT22 cells. European Journal of Pharmacology 617: 1-11. [PMID: 19580806] 

45. Wang P, Wen Y, Han GZ, Sidhu PK and Zhu BT* [2009] Characterization of the estrogenic activity of non-aromatic steroids: Are there male-specific estrogen receptor modulators? British Journal of Pharmacology 158: 1796-1807. [PMID: 19888961] 

46. Fu XM and Zhu BT* [2009] Human pancreas-specific protein disulfide isomerase homolog (PDIp) is an intracellular estrogen-binding protein that modulates estrogen levels and actions in target cells. Journal of Steroid Biochemistry and Molecular Biology 115: 20-29. [PMID: 19429457] 

47. Zhou R, Fukui M, Choi HJ and Zhu BT* [2009] Induction of a reversible, non-cytotoxic S phase delay by resveratrol: Implications for a mechanism of lifespan prolongation and cancer protection. British Journal of Pharmacology 158: 462-474 [PMID: 19563536] 

48. Fu X and Zhu BT* [2009] Human pancreas-specific protein disulfide isomerase homolog (PDIp) is redox-regulated through formation of an inter-subunit disulfide bond. Archives of Biochemistry and Biophysics 485: 1-9. [PMID: 19150607] 

49. Dai X and Zhu BT* [2009] Suppression of T-cell response and prolongation of allograft survival in a rat model by tryptophan catabolites. European Journal of Pharmacology 606: 225-232. [PMID: 19374879] 

50. Funeshima-Fuji N, Fujino M, Xie L, Kimura H, Takahara S, Ezaki T, Zhu BT and Li XK* [2009] Prolongation of rat major histocompatibility complex-compatible cardiac allograft survival during pregnancy. Journal of Heart and Lung Transplantation 28: 176-182. [PMID: 19201344]

51. Bai HW and Zhu BT* [2009] Identification of a novel haplotype of the human catechol-O-methyltransferase gene. Pharmacogenetics and Pharmacogenomics 19: 87-89. [PMID: 19077667]

52. Zhu BT*, Wang P, Nagai M, Wen Y and Bai HW [2009] Inhibition of human catechol-O-methyltransferase (COMT)-mediated O-methylation of catechol estrogens by major polyphenolic components present in coffee. Journal of Steroid Biochemistry and Molecular Biology 113: 65-74. [PMID: 19095062] 

53. Fukui M and Zhu BT* [2009] Mechanisms of 2-methoxyestradiol-induced apoptosis in human breast cancer cells. Molecular Carcinogenesis 48: 66-78. [PMID: 18521846] 

54. Zhu BT* [2008] Differential activation of the human estrogen receptor α and β in postmenopausal hormone replacement therapy: An important parameter for achieving optimal health outcome. Medical Hypotheses and Research 4: 51-61.

55. Fu X, Wang P and Zhu BT* [2008] Protein disulfide isomerase is a multifunctional regulator of estrogenic status in target cells. Journal of Steroid Biochemistry and Molecular Biology 112: 127-137. [PMID: 18840527]

56. Bai HW, Wang P and Zhu BT* [2008] Characterization of a novel mutant of human catechol-O-methyltransferase with triplet point mutations. International Journal of Molecular Medicine 22: 769-780. (Figure 6 of this paper is featured on the journal cover for that issue.) [PMID: 19020775]

57. Bai HW and Zhu BT* [2008] Strong activation of cyclooxygenase I and II catalytic activity by dietary bioflavonoids. Journal of Lipid Research 49: 2557-2570. [PMID: 18660529] 

58. Jiang XR, Wang P, Fu X and Zhu BT* [2008] Chemical synthesis and biochemical characterization of a biotinylated derivative of 17β-estradiol with a long side chain covalently attached to its C-7α position. Steroids 73: 1252-1261. [PMID: 18621069] 

59. Mills LH, Yu J, Xu XM, Lee AJ and Zhu BT* [2008] Naturally-occurring estradiol-17b-fatty acid esters, but not estradiol-17b, preferentially induce mammary tumorigenesis in female rats: Implications for an important role in human breast cancer. Toxicology and Applied Pharmacology 229: 332-341. [PMID: 18394671] 

60. Ding J and Zhu BT* [2008] Unique effect of the pregnancy hormone estriol on antigen-induced production of specific antibodies in female BALB/c mice. Steroids 73: 289-298. [PMID: 18093630] 

61. Zhu BT*, Shim JY, Nagai M and Bai HW [2008] Molecular mechanism for the high-potency inhibition of human catechol-O-methyltransferase by (-)-epigallocatechin-3-O-gallate. Xenobiotica 38: 130-146. [PMID: 18197555] 

62. Zhu BT*, Gallo MA, Burger CW Jr, Meeker RJ, Cai MX, Xu S and Conney AH [2008] Effect of 2,3,7,8-tetrachlorodibenzo-p-dioxin administration and high-fat diet on the body weight and hepatic estrogen metabolism in female C3H/HeN mice. Toxicology and Applied Pharmacology 226: 107-118. [PMID: 17945325] 

63. Zhu BT* [2008] Is it necessary to control the level of estrogen receptor α and β activation in postmenopausal hormone replacement therapy in order to achieve the optimal outcome? Molecular Medicine Reports 1: 15-20 (This is an invited paper for the inaugural issue.) [PMID: 21479371] 

64. Chen AY, Lee AJ and Zhu BT* [2007] Chemical synthesis of six novel 17β-estradiol and estrone dimers and study of their formation catalyzed by human cytochrome P450 isoforms. Journal of Medicinal Chemistry 50: 5372-5381. [PMID: 17924615] 

65. Bai HW, Shim JY, Yu J and Zhu BT* [2007] Biochemical and molecular modeling studies of the O-methylation of various endogenous and exogenous catechol substrates catalyzed by recombinant human soluble and membrane-bound catechol-O-methyltransferases. Chemical Research in Toxicology 20: 1409-1425. [PMID: 17880176]

66. Takemura H, Shim JY, Sayama K, Tsubura A, Zhu BT and Shimoi K* [2007] Characterization of the estrogenic activities of Zearalenone and Zeranol in vivo and in vitro. Journal of Steroid Biochemistry and Molecular Biology 103: 170-177. [PMID: 17097287] 

67. Zhu BT*, Han GZ, Shim JY, Wen Y and Jiang XR [2006] Quantitative structure-activity relationship of various endogenous estrogen metabolites for human estrogen receptor α and β subtypes: Insights into the structural determinants favoring a differential subtype binding. Endocrinology 147: 4132-4150. [PMID: 16728493]  

68. Vijayanathan V, Venkiteswaran S, Nair SK, Verma A, Thomas TJ, Zhu BT and Thomas T* [2006] Physiological levels of 2-methoxyestradiol interfere with nongenomic signaling of 17β-estradiol in human breast cancer cells. Clinical Cancer Research 12: 2038-2048. [PMID: 16609013] 

69. Jiang XR, Sowell JW and Zhu BT* [2006] Synthesis of 7a-substituted derivatives of 17β-estradiol. Steroids 71: 334-342. [PMID: 16563449]

70. Lee WJ and Zhu BT* [2006] Inhibition of DNA methylation by caffeic acid and chlorigenic acid, two common catechol-containing coffee polyphenols. Carcinogenesis 27: 269-277. [PMID: 16081510] 

71. Lee WJ, Shim JY and Zhu BT* [2005] Mechanisms for inhibition of DNA methyltransferases by tea catechins and bioflavonoids. Molecular Pharmacology 68: 1018-1030. [Figure 11 of this paper was featured on the journal cover.] [PMID: 16037419] 

72. Zhu BT* [2005] Mechanistic explanation for the unique pharmacologic properties of receptor partial agonists. Biomedicine and Pharmacotherapy 59: 76-89. [PMID: 15795100] 

73. Zhu BT* [2005] Human and animal spongiform encephalopathies are the result of chronic autoimmune attack in the CNS: A novel medical theory supported by overwhelming experimental evidence. Histology and Histopathology 20: 575-592. [PMID: 15736062] 

74. Zhu BT* and Lee AJ [2005] NADPH-dependent metabolism of 17β-estradiol and estrone to polar and nonpolar metabolites by human tissues and cytochrome P450 isoforms. Steroids 70: 225-244. [PMID: 15784278] 

75. Lee WJ and Zhu BT* [2005] Modulation of DNA methylation by catechol-O-methyltransferase. Medical Hypotheses and Research 2: 325-337.

76. Liu ZJ, Lee WJ and Zhu BT* [2005] Selective insensitivity of ZR-75-1 human breast cancer cells to 2-methoxyestradiol: Evidence for Type II 17b-hydroxysteroid dehydrogenase as the underlying cause. Cancer Research 65: 5802-5811. [PMID: 15994956]

77. Zhu BT* [2005] Human and animal spongiform encephalopathies are autoimmune diseases: A novel theory and its supporting evidence. International Review of Neurobiology 63:155-190. [PMID: 15797468] 

78. Zhu BT* [2005] Roles of CNS oxidation and methylation of dopamine neurotransmitter in Parkinson's disease. In: Focus on Parkinson's Disease Research. Marianne J. Willow (editor). pp. 21-43.

79. Han GZ, Liu ZJ, Shimoi K and Zhu BT* [2005] Synergism between the anticancer actions of 2-methoxyestradiol and microtubule-disrupting agents in human breast cancer. Cancer Research 65: 387-393. [PMID: 15695378] 

80. Takemura H, Jie M, Sayama K, Terao Y, Zhu BT and Shimoi K* [2005] In vitro and in vivo estrogenic activity of chlorinated derivatives of bisphenol A. Toxicology 207: 215-221. [PMID: 15596252] 

81. Yu J, Liu ZJ, Han GZ, Lee AJ and Zhu BT* [2004] Precipitous dose-response curves for the anticancer actions of microtubule-disrupting agents in human breast cancer cells: Implications for high-dose regimen in anticancer chemotherapy. Medical Hypotheses and Research 1: 267-274.

82. Lee JA and Zhu BT* [2004] NADPH-dependent formation of polar and nonpolar estrogen metabolites following incubations of 17β-estradiol with human liver microsomes. Drug Metabolism and Disposition 32: 876-883. [PMID: 15258114]

83. Nagai M, Conney AH and Zhu BT* [2004] Strong inhibitory effects of common tea catechins and bioflavonoids on the O-methylation of catechol estrogens catalyzed by human liver cytosolic catechol-O-methyltransferase. Drug Metabolism and Disposition 32: 497-504. [PMID: 15100171]

84. Lee AJ, Sowell JW, Cotham WE and Zhu BT* [2004] Chemical synthesis of two novel diaryl ether dimers of estradiol-17β. Steroids 69: 61-65. [PMID: 14715378] 

85. Liu ZJ and Zhu BT* [2004] Concentration-dependent mitogenic and antiproliferative actions of 2-methoxyestradiol in estrogen receptor-positive human breast cancer cells. Journal of Steroid Biochemistry and Molecular Biology 88: 265-275. [PMID: 15120420]

86. Zhu BT* [2004] CNS dopamine oxidation and catechol-O-methyltransferase (COMT): Importance in the etiology, pharmacotherapy, and dietary prevention of Parkinson’s disease. International Journal of Molecular Medicine 13: 343-354. [PMID: 14767563] 

87. Lee AJ, Pellechia PJ, Walla MD and Zhu BT* [2004] Characterization of a novel class of nonpolar 17b-estradiol metabolites formed by human cytochrome P450 enzymes. Medical Hypotheses and Research 1: 53-65. 

88. Lee AJ, Conney AH and Zhu BT* [2003] Human cytochrome P450 3A7 has a distinct high catalytic activity for the 16α-hydroxylation of estrone, but not 17β-estradiol. Cancer Research 63: 6532-6536. [PMID: 14559847]

89. Lee AJ, Cai MX, Thomas PE, Conney AH and Zhu BT* [2003] Characterization of the oxidative metabolites of 17β-estradiol and estrone formed by fifteen selectively-expressed human cytochrome P450 isoforms. Endocrinology 144: 3382-3398. [PMID: 12865317] 

90. Zhu BT* [2003] Medical hypothesis: Hyperhomocysteinemia is a risk factor for estrogen-induced hormonal cancer. International Journal of Oncology 22: 499-508. [PMID: 12579301] 

91. Zhu BT* [2002] On the mechanism of homocysteine pathophysiology and pathogenesis: A unifying hypothesis. Histology and Histopathology 17: 1283-1291. [PMID: 12371153]

92. Zhu BT* [2002] Catechol-O-methyltransferase (COMT)-mediated methylation metabolism of endogenous bioactive catechols and modulation by endobiotics and xenobiotics: Importance in pathophysiology and pathogenesis. Current Drug Metabolism 3: 321-349. [PMID: 12083324] 

93. Lee AJ, Mills LH, Kosh JW, Conney AH and Zhu BT* [2002] NADPH-dependent metabolism of estrone by human liver microsomes. Journal of Pharmacology and Experimental Therapeutics 300: 838-849. [PMID: 11861789] 

94. Zhu BT*, Cai MX, Spink DC, Hussain MM, Busch C, Ranzini A, Lambert GH, Thomas PE and Conney AH [2002] Stimulatory effect of cigarette smoking on the 15α-hydroxylation of 17β-estradiol by human term placenta. Clinical Pharmacology and Therapeutics 71: 311-324 [PMID: 12011817] 

95. Xu S, Zhu BT and Conney AH [2002] Effect of clofibrate administration on the esterification and deesterification of steriod hormones by liver and extrahepatic tissues in rats. Biochemical Pharmacology 63: 985-992. [PMID: 11911851] 

96. Zhu BT* [2002] On the mechanism of action and physiological functions of P-glycoprotein: Some critical thoughts. Recent Research Developments in Drug Metabolism and Disposition 1: 25-42. 

97. Zhu BT*, Patel UK, Cai MX, Lee AJ and Conney AH [2001] Rapid conversion of tea catechins to monomethylated products by rat liver cytosolic catechol-O-methyltransferase. Xenobiotica 31: 879-890. [PMID: 11780762] 

98. Xu S, Zhu BT, Turan V, Rusyn I, Thurman R, Peters JM, Gonzalez FJ and Conney AH* [2001] PPARα-dependent induction of liver microsomal esterification of estradiol and testosterone by a prototypical peroxisome proliferator. Endocrinology 142: 3554-3557. [PMID: 11459802] 

99. Mills LH, Lee AJ and Parlow AF and Zhu BT* [2001] Preferential growth stimulation of mammary glands over uterine endometrium in female rats by a naturally occurring estradiol-17β-fatty acid ester. Cancer Research 61: 5764-5770. [PMID: 11479213] 

100. Lee AJ, Kosh JW, Conney AH and Zhu BT* [2001] Characterization of the NADPH-dependent metabolism of 17β-estradiol to multiple metabolites by human liver microsomes and selectively-expressed human cytochrome P450 3A4 and 3A5. Journal of Pharmacology and Experimental Therapeutics 298: 420-432. [PMID: 11454902] 

101. Xu S, Zhu BT and Conney AH* [2001] Stimulatory effect of clofibrate on the action of estradiol in the mammary gland but not in the utuers of rats. Journal of Pharmacology and Experimental Therapeutics 297: 50-56. [PMID: 11259527]

102. Xu S, Zhu BT and Conney AH* [2001] Stimulatory effect of clofibrate and gemfibrozil administration on the formation of fatty acid esters of estradiol by rat liver microsomes. Journal of Pharmacology and Experimental Therapeutics 296: 188-197. [PMID: 11123380]  

103. Zhu BT*, Kosh JW, Fu JH, Xu S, Cai MX and Conney AH [2000] Strong inhibition of estrone-3-sulfatase activity by pregnenolone 16α-carbonitrile but not by several analogs lacking a 16α-nitrile group. Steroids 65: 521-527. [PMID: 10978731] 

104. Zhu BT*, Patel UK, Cai MX and Conney AH [2000] Metabolic O-methylation of tea polyphenols catalyzed by human placental cytosolic catechol-O-methyltransferase. Drug Metabolism and Disposition 28: 1024-1030. (Figure 6 of this paper was featured on the journal cover of that issue.) [PMID: 10950844]

105. Zhu BT* [1999] A novel hypothesis for the mechanism of action of P-glycoprotein as a multidrug transporter. Molecular Carcinogenesis 25: 1-13. (Figure 1 of this paper was featured on the journal cover of that issue.) [PMID: 10331739]

106. DiPaola RS*, Zhang H, Lambert G, Mecker R, Licitra E, Rafi MM, Zhu BT, Spaulding H, Goodin S, Toledano MB, Hait WN and Gallo M [1998] Clinical and biologic activity of an estrogenic herbal combination (PC-SPES) in prostate cancer. New England Journal of Medicine 339: 785-791. [PMID: 9738085] 

107. Zhu BT* and Conney AH [1998] Is 2-methoxyestradiol an endogenous estrogen metabolite that inhibits mammary carcinogenesis? Cancer Research 58: 2269-2277. [PMID: 9622057] 

108. Huang MT*, Lou YR, Xie JG, Ma W, Lu YP, Yen P, Zhu BT, Newmark H and Ho CT [1998] Effect of dietary curcumin and dibenzoylmethane on formation of 7,12-dimethylbenz[a]anthracene-induced mammary tumors and lymphomas/leukemias in Sencar mice. Carcinogenesis 19: 1697-1700. [PMID: 9771944]

109. Zhu BT, Loder DP, Cai MX, Ho CT, Huang MT and Conney AH* [1998] Dietary administration of an extract from rosemary leaves enhances the liver microsomal metabolism of estrogens and decreases their uterotropic action in CD-1 mice. Carcinogenesis 19: 1821-1827. [PMID: 9806165] 

110. Zhu BT*, Fu JH, Xu S, Kauffman FC and Conney AH [1998] Different biochemical properties of nuclear and microsomal estrone-3-sulfatases: Evidence for the presence of a nuclear isozyme. Biochemical and Biophysical Research Communications 246: 45-49. [PMID: 9600065] 

111. Zhu BT, Taneja N, Loder DP, Balentine DA and Conney AH* [1998] Effects of tea polyphenols and flavonoids on liver microsomal glucuronidation of estradiol and estrone. Journal of Steroid Biochemistry and Molecular Biology 64: 207-215. [PMID: 9605416] 

112. Zhu BT and Conney AH* [1998] Functional role of estrogen metabolism in target cells: Review and perspectives. Carcinogenesis 19: 1-27. [PMID: 9472688]  PDF

113. Zhu BT* and Fu JH [1997] Uterine estrogen sulfatase may play a more important role than the hepatic sulfatase in mediating the uterotropic action of estrone-3-sulfate. Endocrine 7: 191-198. [PMID: 9549045] 

114. Sarabia SF, Zhu BT, Kurosawa T, Tohma M and Liehr JG* [1997] Mechanism of cytochrome P450-catalyzed aromatic hydroxylation of estrogens. Chemical Research in Toxicology 10: 767-771. [PMID: 9250410]

115. Hammond DK, Zhu BT, Wang MY, Ricci MJ and Liehr JG* [1997] Cytochrome P450 metabolism of estradiol in hamster liver and kidney. Toxicology and Applied Pharmacology 145: 54-60. [PMID: 9221823] 

116. Zhu BT, Lech J, Rosen RT and Conney AH* [1997] Effect of dietary 2(3)-tert-butyl-4-hydroxyanisole on the metabolism and action of estradiol and estrone in female CD-1 mice. Cancer Research 57: 2419-2427. [PMID: 9192820] 

117. Zhu BT* [1996] Rational design of receptor partial agonists and possible mechanisms of receptor partial activation: A theory. Journal of Theoretical Biology 181: 273-291. [PMID: 8869127]

118. Zhu BT and Liehr JG* [1996] Inhibition of catechol O-methyltransferase-catalyzed O-methylation of 2- and 4-hydroxyestradiol by quercetin: Possible role in estradiol-induced tumorigenesis. Journal of Biological Chemistry 271: 1357-1363. [PMID: 8576124] 

119. Zhu BT, Evaristus EN, Antoniak SK, Sarabia SF, Ricci MJ and Liehr JG* [1996] Metabolic deglucuronidation and demethylation of estrogen conjugates as a source of parent estrogens and catecholestrogen metabolites in Syrian hamster kidney, a target organ of estrogen-induced tumorigenesis. Toxicology and Applied Pharmacology 136: 186-193. [PMID: 8560473] 

120. Zhu BT, Suchar LA, Huang MT and Conney AH* [1996] Similarities and differences in the glucuronidation of estradiol and estrone by UDP-glucuronosyltransferase in liver microsomes from male and female rats. Biochemical Pharmacology 51: 1195-1202. [PMID: 8645343]

121. Zhu BT*, Suchar LA, Gywnne M and Huang MT [1995] Effect of age and sex on the inducibility of hepatic microsomal 4-nitrophenol UDP-glucuronyltransferase activity in rats. Life Sciences 57: PL19-PL24. [PMID: 7596214]

122. Chu YH* and Zhu BT [1995] An in-vitro bioassay for testing the direct effect of luteinizing hormone-releasing hormone agonists on progesterone secretion by rat ovarian cells. Life Sciences 57: 2031-2039. [PMID: 7475954] 

123. Liehr JG, Ricci MJ, Jefcoate CR, Hanningan EV, Hokanson JA and Zhu BT [1995] 4‑Hydroxylation of estradiol by human uterine myometrium and myoma microsomes: Implications for the mechanism of uterine tumorigenesis. Proceedings of the National Academy of Sciences of USA 92: 9220-9224. [PMID: 7568105] 

124. Zhu BT, Bui QD, Weisz J and Liehr JG* [1994] Conversion of estrone to 2‑ and 4‑hydroxyestrone by hamster kidney and liver microsomes: Implications for the mechanism of estrogen‑induced carcinogenesis. Endocrinology 135: 1772-1779. [PMID: 7956900] 

125. Zhu BT and Liehr JG* [1994] Quercetin increases the severity of estradiol-induced tumorigenesis in hamster kidney. Toxicology and Applied Pharmacology 125: 149-158. [PMID: 8128490] 

126. Zhu BT, Ezell EL and Liehr JG* [1994] Catechol‑O‑methyltransferase‑catalyzed O‑methylation of mutagenic flavonoids: Metabolic inactivation as possible reason for their lack of carcinogenicity in vivo. Journal of Biological Chemistry 269: 292‑299. [PMID: 8276810] 

127. Zhu BT* [1994] Agonist-antagonist hybrids: A strategy for the rational design of receptor partial agonists. Medicinal Chemistry Research 4: 367-384.

128. Zhu BT* [1993] The competitive and noncompetitive antagonism of receptor‑mediated drug actions in the presence of spare receptors. Journal of Pharmacological and Toxicological Methods 29: 85‑91. [PMID: 8318718] 

129. Zhu BT and Liehr JG* [1993] Inhibition of the catechol‑O‑methyltransferase-catalyzed O‑methylation of 2‑ and 4‑hydroxyestradiol by catecholamines: Implications for the mechanism of estrogen‑induced carcinogenesis. Archives of Biochemistry and Biophysics 304: 248‑256. [PMID: 8323288] 

130. Zhu BT, Roy D and Liehr JG* [1993] The carcinogenic activity of ethinyl estrogens is determined by both their hormonal characteristics and their conversion to catechol metabolites. Endocrinology 132: 577‑583. [PMID: 8381068] 

131. Seitz P, Zhu BT and Cooper CW* [1992] Effect of transforming growth factor-β on parathyroid hormone receptor binding and cAMP formation in rat osteosarcoma cells. Journal of Bone and Mineral Research 7: 541‑546. [PMID: 1319667] 

132. Zhou MH, Zhu BT, Han GZ and Chu YH [1991] Effect of amino acid residue substitutions at positions 5, 6, and 8 of luteinizing hormone-releasing hormone (LHRH) on its bioactivity. Chinese Journal of Pharmaceuticals 22: 208-211.

133. Zhu BT and Chu YH [1990] Study on the pregnancy-disrupting effect of a luteinizing hormone-releasing hormone agonist in mid‑gestational rats. Acta Pharmaceutica Sinica (Yao Xue Xue Bao) 25: 490-493. [PMID: 2085123]

134. Zhu BT, Chu YH, Chu JY and Liu YZ [1990] A new method for comparing the bioactivity of luteinizing hormone-releasing hormone (LHRH) and its analogs. Chinese Journal of Pharmaceuticals 21: 63-66.

135. Zhu BT, Chu YH, Chu JY and Liu YZ [1990] Direct effect of LHRH and its three analogs on progesterone secretion by early pregnant human luteal cells in vitro. Acta Academiae Medicinae Shanghai 17: 11-15.

136. Zhu BT and Chu YH [1990] Effects of a luteinizing hormone-releasing hormone agonist on the secretion of human chorionic gonadotropin (hCG) and progesterone by human placental tissues in vitro. Chinese Journal of Pharmaceuticals 21: 119-122.

137. Zhu BT and Chu YH [1990] The effect of HCG and LHRH analogs on progesterone secretion by human placenta cells of early and term gestation in vitro. Acta Pharmaceutica Sinica (Yao Xue Xue Bao) 25: 469-472.

138. Chu JY, Ding JF, Liu YZ, Zhu BT and Chu YH [1989] Design and synthesis of novel luteinizing hormone-releasing hormone analogs. Acta Pharmaceutica Sinica (Yao Xue Xue Bao) 24: 95-98. [PMID: 2678892]